Reaction Details |
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Target | Sodium-dependent noradrenaline transporter |
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Ligand | BDBM50216245 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_456613 (CHEMBL922968) |
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Ki | 460±n/a nM |
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Citation | Keith, JM; Gomez, LA; Barbier, AJ; Wilson, SJ; Boggs, JD; Lord, B; Mazur, C; Aluisio, L; Lovenberg, TW; Carruthers, NI Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors. Bioorg Med Chem Lett17:4374-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent noradrenaline transporter |
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Name: | Sodium-dependent noradrenaline transporter |
Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 69337.72 |
Organism: | Homo sapiens (Human) |
Description: | P23975 |
Residue: | 617 |
Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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BDBM50216245 |
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n/a |
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Name | BDBM50216245 |
Synonyms: | (6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin-3-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | CHEMBL247933 |
Type | Small organic molecule |
Emp. Form. | C25H33N3O |
Mol. Mass. | 391.549 |
SMILES | C(COc1ccc2[C@@H](CN3CCC[C@@H]3c2c1)c1cccnc1)CN1CCCCC1 |
Structure |
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