Reaction Details |
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Target | Cannabinoid receptor 1 |
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Ligand | BDBM50217214 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_440533 (CHEMBL889632) |
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IC50 | 1.8±n/a nM |
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Citation | Liu, P; Lin, LS; Hamill, TG; Jewell, JP; Lanza, TJ; Gibson, RE; Krause, SM; Ryan, C; Eng, W; Sanabria, S; Tong, X; Wang, J; Levorse, DA; Owens, KA; Fong, TM; Shen, CP; Lao, J; Kumar, S; Yin, W; Payack, JF; Springfield, SA; Hargreaves, R; Burns, HD; Goulet, MT; Hagmann, WK Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use. J Med Chem50:3427-30 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cannabinoid receptor 1 |
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Name: | Cannabinoid receptor 1 |
Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52868.96 |
Organism: | Homo sapiens (Human) |
Description: | P21554 |
Residue: | 472 |
Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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BDBM50217214 |
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n/a |
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Name | BDBM50217214 |
Synonyms: | CHEMBL226640 | N-{(1S,2S)-2-(3-cyanophenyl)-3-[4-(2-fluoroethoxy)phenyl]-1-methylpropyl}-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide |
Type | Small organic molecule |
Emp. Form. | C28H28F4N4O3 |
Mol. Mass. | 544.5405 |
SMILES | C[C@H](NC(=O)C(C)(C)Oc1cc(ncn1)C(F)(F)F)[C@@H](Cc1ccc(OCCF)cc1)c1cccc(c1)C#N |
Structure |
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