| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
|---|
| Ligand | BDBM50218177 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_457030 (CHEMBL924394) |
|---|
| Ki | 50±n/a nM |
|---|
| Citation |  Lafontaine, JA; Day, RF; Dibrino, J; Hadcock, JR; Hargrove, DM; Linhares, M; Martin, KA; Maurer, TS; Nardone, NA; Tess, DA; Dasilva-Jardine, P Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity. Bioorg Med Chem Lett17:5245-50 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-1 adrenergic receptor |
|---|
| Name: | Beta-1 adrenergic receptor |
|---|
| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 51338.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08588 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
|
|
|
|---|
| BDBM50218177 |
|---|
| n/a |
|---|
| Name | BDBM50218177 |
|---|
| Synonyms: | (R)-2-(2-(4-(2-(benzyloxymethyl)oxazol-4-yl)phenoxy)ethylamino)-1-(pyridin-3-yl)ethanol | CHEMBL250760 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H27N3O4 |
|---|
| Mol. Mass. | 445.5103 |
|---|
| SMILES | O[C@@H](CNCCOc1ccc(cc1)-c1coc(COCc2ccccc2)n1)c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
