| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
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| Ligand | BDBM50218164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457035 (CHEMBL924399) |
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| EC50 | 13±n/a nM |
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| Citation |  Lafontaine, JA; Day, RF; Dibrino, J; Hadcock, JR; Hargrove, DM; Linhares, M; Martin, KA; Maurer, TS; Nardone, NA; Tess, DA; Dasilva-Jardine, P Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity. Bioorg Med Chem Lett17:5245-50 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-3 adrenergic receptor |
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| Name: | Beta-3 adrenergic receptor |
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| Synonyms: | ADRB3_RAT | Adrb3 | Adrb3r | Adrenergic receptor beta | Beta-3 adrenergic receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43161.83 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1509452 |
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| Residue: | 400 |
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| Sequence: | MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIA
RTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTA
SIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGAD
AEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELG
RFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSL
CWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSY
GGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
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| BDBM50218164 |
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| n/a |
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| Name | BDBM50218164 |
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| Synonyms: | (R)-2-(2-(4-(2-methylthiazol-4-yl)phenoxy)ethylamino)-1-(pyridin-3-yl)ethanol | CHEMBL251599 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N3O2S |
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| Mol. Mass. | 355.454 |
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| SMILES | Cc1nc(cs1)-c1ccc(OCCNC[C@H](O)c2cccnc2)cc1 |
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| Structure | 
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