| Reaction Details |
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 | Report a problem with these data |
| Target | Progesterone receptor |
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| Ligand | BDBM50219539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457222 (CHEMBL940823) |
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| IC50 | 520±n/a nM |
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| Citation |  Higuchi, RI; Thompson, AW; Chen, JH; Caferro, TR; Cummings, ML; Deckhut, CP; Adams, ME; Tegley, CM; Edwards, JP; López, FJ; Kallel, EA; Karanewsky, DS; Schrader, WT; Marschke, KB; Zhi, L Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones. Bioorg Med Chem Lett17:5442-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Progesterone receptor |
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| Name: | Progesterone receptor |
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| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
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| Type: | Protein |
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| Mol. Mass.: | 98979.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06401 |
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| Residue: | 933 |
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| Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
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| BDBM50219539 |
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| n/a |
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| Name | BDBM50219539 |
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| Synonyms: | (R)-3-ethyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-3,4-dihydro-2H-[1,4]oxazino[2,3-f]quinolin-8(7H)-one | CHEMBL250897 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14F6N2O2 |
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| Mol. Mass. | 380.285 |
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| SMILES | CC[C@@H]1COc2c(ccc3[nH]c(=O)cc(c23)C(F)(F)F)N1CC(F)(F)F |r| |
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| Structure | 
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