Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50220524 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_449280 (CHEMBL899542) |
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Ki | 8.2±n/a nM |
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Citation | Keith, JM; Barbier, AJ; Wilson, SJ; Miller, K; Boggs, JD; Fraser, IC; Mazur, C; Lovenberg, TW; Carruthers, NI Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores. Bioorg Med Chem Lett17:5325-9 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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BDBM50220524 |
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n/a |
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Name | BDBM50220524 |
Synonyms: | 2-methyl-4-(4-(methylthio)phenyl)-7-(5-(piperidin-1-ylmethyl)pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline | CHEMBL237862 |
Type | Small organic molecule |
Emp. Form. | C28H33N3OS |
Mol. Mass. | 459.646 |
SMILES | CSc1ccc(cc1)C1CN(C)Cc2cc(Oc3ccc(CN4CCCCC4)cn3)ccc12 |w:8.8| |
Structure |
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