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TargetSodium-dependent serotonin transporter
LigandBDBM50220533
Substrate/Competitorn/a
Meas. Tech.ChEMBL_449279 (CHEMBL899541)
Ki 616±n/a nM
Citation Keith, JMBarbier, AJWilson, SJMiller, KBoggs, JDFraser, ICMazur, CLovenberg, TWCarruthers, NI Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores. Bioorg Med Chem Lett17:5325-9 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent serotonin transporter
Name:Sodium-dependent serotonin transporter
Synonyms:5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:Multi-pass membrane protein
Mol. Mass.:70322.51
Organism:Homo sapiens (Human)
Description:P31645
Residue:630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50220533
n/a
NameBDBM50220533
Synonyms:2-methyl-4-(4-(methylthio)phenyl)-5-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline | CHEMBL236605
TypeSmall organic molecule
Emp. Form.C29H34N2OS
Mol. Mass.458.658
SMILESCSc1ccc(cc1)C1CN(C)Cc2cccc(Oc3cccc(CN4CCCCC4)c3)c12 |w:8.8|
Structure
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