| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50221751 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_446223 (CHEMBL895328) |
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| IC50 | >10000±n/a nM |
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| Citation |  La Motta, C; Sartini, S; Mugnaini, L; Simorini, F; Taliani, S; Salerno, S; Marini, AM; Da Settimo, F; Lavecchia, A; Novellino, E; Cantore, M; Failli, P; Ciuffi, M Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity. J Med Chem50:4917-27 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50221751 |
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| n/a |
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| Name | BDBM50221751 |
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| Synonyms: | 2-(3,4-dihydroxyphenyl)-6-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one | CHEMBL242416 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10N2O4 |
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| Mol. Mass. | 270.2402 |
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| SMILES | Oc1ccc(cc1O)-c1cc(=O)n2c(O)cccc2n1 |
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| Structure | 
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