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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 4 | ||
| Ligand | BDBM50221984 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_449743 (CHEMBL898850) | ||
| IC50 | 4.6±n/a nM | ||
| Citation |  Kaelin, DE; Smenton, AL; Eiermann, GJ; He, H; Leiting, B; Lyons, KA; Patel, RA; Patel, SB; Petrov, A; Scapin, G; Wu, JK; Thornberry, NA; Weber, AE; Duffy, JL 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett17:5806-11 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 4 | |||
| Name: | Dipeptidyl peptidase 4 | ||
| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 88271.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27487 | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM50221984 | |||
| n/a | |||
| Name | BDBM50221984 | ||
| Synonyms: | (2S,3S)-2-amino-1-(3,3-difluoropyrrolidin-1-yl)-3-(4-(pyridin-3-yl)cyclohexyl)butan-1-one | CHEMBL237151 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H27F2N3O | ||
| Mol. Mass. | 351.434 | ||
| SMILES | C[C@H]([C@H](N)C(=O)N1CCC(F)(F)C1)C1CCC(CC1)c1cccnc1 |wU:2.2,wD:1.0,(21.02,4.01,;21.02,2.47,;22.36,1.7,;22.36,.16,;23.69,2.47,;23.69,4.01,;25.03,1.7,;26.43,2.32,;27.46,1.17,;26.68,-.16,;25.9,-1.49,;28.19,-.48,;25.17,.16,;19.68,1.7,;19.68,.15,;18.35,-.61,;17.02,.15,;17.02,1.7,;18.35,2.47,;15.69,-.62,;14.36,.14,;13.03,-.63,;13.03,-2.17,;14.37,-2.93,;15.69,-2.16,)| | ||
| Structure | 
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