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TargetGrowth hormone secretagogue receptor type 1
LigandBDBM50222166
Substrate/Competitorn/a
Meas. Tech.ChEMBL_449846 (CHEMBL897910)
Ki 820±n/a nM
Citation Hernández, ASCheng, PTMusial, CMSwartz, SGGeorge, RJGrover, GSlusarchyk, DSeethala, RKSmith, MDickinson, KGiupponi, LLonghi, DAFlynn, NMurphy, BJGordon, DABiller, SARobl, JATino, JA Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues. Bioorg Med Chem Lett17:5928-33 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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  Blast E-value cutoff:
BDBM50222166
n/a
NameBDBM50222166
Synonyms:2-amino-N-((S)-2-benzyloxy-1-{1-[2-(3-phenyl-propylcarbamoyl)-ethyl]-1H-tetrazol-5-yl}-ethyl)-2-methyl-propionamide | CHEMBL235011
TypeSmall organic molecule
Emp. Form.C26H35N7O3
Mol. Mass.493.6012
SMILESCC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1
Structure
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