| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase TEM |
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| Ligand | BDBM50225385 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_451362 (CHEMBL901565) |
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| Ki | 800±n/a nM |
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| Citation |  Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. J Med Chem50:5644-54 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase TEM |
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| Name: | Beta-lactamase TEM |
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| Synonyms: | BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla |
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| Type: | Enzyme |
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| Mol. Mass.: | 31512.33 |
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| Organism: | Escherichia coli |
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| Description: | P62593 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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| BDBM50225385 |
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| n/a |
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| Name | BDBM50225385 |
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| Synonyms: | CHEMBL391537 | pinacol 5-[(4-morpholin-4-yl-phenylamino)methyl]benzo[b]-thiophen-2-ylboronate |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21BN2O3S |
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| Mol. Mass. | 368.258 |
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| SMILES | OB(O)c1cc2cc(CNc3ccc(cc3)N3CCOCC3)ccc2s1 |
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| Structure | 
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