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TargetFarnesyl diphosphate synthase
LigandBDBM50225999
Substrate/Competitorn/a
Meas. Tech.ChEMBL_451825
IC50 16.4±n/a nM
Citation Marma MSXia ZStewart CCoxon FDunford JEBaron RKashemirov BAEbetino FHTriffitt JTRussell RGMcKenna CE Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. J Med Chem 50:5967-75 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Farnesyl diphosphate synthase
Name:Farnesyl diphosphate synthase
Synonyms:Dimethylallyltranstransferase | FPP synthase | FPP synthetase | FPS | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | P14324
Type:Enzyme
Mol. Mass.:48272.89
Organism:Homo sapiens (Human)
Description:P14324
Residue:419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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  Blast E-value cutoff:
BDBM50225999
n/a
NameBDBM50225999
Synonyms:1-fluoro-2-(3-pyridinyl)-ethylidene-1,1-bisphosphonic acid | CHEMBL437758
TypeSmall organic molecule
Emp. Form.C7H10FNO6P2
Mol. Mass.285.1033
SMILESOP(O)(=O)C(F)(Cc1cccnc1)P(O)(O)=O
Structure
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