Reaction Details |
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Target | Cytochrome P450 2C19 |
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Ligand | BDBM50226483 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_452018 (CHEMBL901178) |
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IC50 | >900000±n/a nM |
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Citation | Poel, TJ; Thomas, RC; Adams, WJ; Aristoff, PA; Barbachyn, MR; Boyer, FE; Brieland, J; Brideau, R; Brodfuehrer, J; Brown, AP; Choy, AL; Dermyer, M; Dority, M; Ford, CW; Gadwood, RC; Hanna, D; Hongliang, C; Huband, MD; Huber, C; Kelly, R; Kim, JY; Martin, JP; Pagano, PJ; Ross, D; Skerlos, L; Sulavik, MC; Zhu, T; Zurenko, GE; Prasad, JV Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. J Med Chem50:5886-9 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C19 |
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Name: | Cytochrome P450 2C19 |
Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
Type: | Enzyme |
Mol. Mass.: | 55935.47 |
Organism: | Homo sapiens (Human) |
Description: | P33261 |
Residue: | 490 |
Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
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BDBM50226483 |
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n/a |
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Name | BDBM50226483 |
Synonyms: | (5R)-3-[3-fluoro-4-(1-oxidotetrahydro-2H-thiopyran-4-yl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamide | CHEMBL437955 | PF-00422602 |
Type | Small organic molecule |
Emp. Form. | C15H17FN2O4S |
Mol. Mass. | 340.37 |
SMILES | NC(=O)[C@H]1CN(C(=O)O1)c1ccc(C2CCS(=O)CC2)c(F)c1 |
Structure |
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