| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50226483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_452020 (CHEMBL901180) |
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| IC50 | >900000±n/a nM |
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| Citation |  Poel, TJ; Thomas, RC; Adams, WJ; Aristoff, PA; Barbachyn, MR; Boyer, FE; Brieland, J; Brideau, R; Brodfuehrer, J; Brown, AP; Choy, AL; Dermyer, M; Dority, M; Ford, CW; Gadwood, RC; Hanna, D; Hongliang, C; Huband, MD; Huber, C; Kelly, R; Kim, JY; Martin, JP; Pagano, PJ; Ross, D; Skerlos, L; Sulavik, MC; Zhu, T; Zurenko, GE; Prasad, JV Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. J Med Chem50:5886-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50226483 |
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| n/a |
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| Name | BDBM50226483 |
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| Synonyms: | (5R)-3-[3-fluoro-4-(1-oxidotetrahydro-2H-thiopyran-4-yl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamide | CHEMBL437955 | PF-00422602 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17FN2O4S |
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| Mol. Mass. | 340.37 |
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| SMILES | NC(=O)[C@H]1CN(C(=O)O1)c1ccc(C2CCS(=O)CC2)c(F)c1 |
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| Structure | 
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