| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50228948 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_461718 (CHEMBL928849) |
|---|
| Ki | 80±n/a nM |
|---|
| Citation |  Young, RJ; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chan, C; Charbaut, M; Chung, CW; Convery, MA; Kelly, HA; Paul King, N; Kleanthous, S; Mason, AM; Pateman, AJ; Patikis, AN; Pinto, IL; Pollard, DR; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs. Bioorg Med Chem Lett18:23-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50228948 |
|---|
| n/a |
|---|
| Name | BDBM50228948 |
|---|
| Synonyms: | 6-chloro-N-(2-oxo-1-(5-phenylpyridin-2-yl)pyrrolidin-3-yl)naphthalene-2-sulfonamide | CHEMBL442293 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H20ClN3O3S |
|---|
| Mol. Mass. | 477.963 |
|---|
| SMILES | Clc1ccc2cc(ccc2c1)S(=O)(=O)NC1CCN(C1=O)c1ccc(cn1)-c1ccccc1 |w:15.16| |
|---|
| Structure | 
|
|---|
Search and Browse
