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TargetCoagulation factor X
LigandBDBM50228948
Substrate/Competitorn/a
Meas. Tech.ChEMBL_461718
Ki 80±n/a nM
Citation Young RJBorthwick ADBrown DBurns-Kurtis CLCampbell MChan CCharbaut MChung CWConvery MAKelly HAPaul King NKleanthous SMason AMPateman AJPatikis ANPinto ILPollard DRSenger SShah GPToomey JRWatson NSWeston HE Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs. Bioorg Med Chem Lett 18:23-7 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50228948
n/a
NameBDBM50228948
Synonyms:6-chloro-N-(2-oxo-1-(5-phenylpyridin-2-yl)pyrrolidin-3-yl)naphthalene-2-sulfonamide | CHEMBL442293
TypeSmall organic molecule
Emp. Form.C25H20ClN3O3S
Mol. Mass.477.963
SMILESClc1ccc2cc(ccc2c1)S(=O)(=O)NC1CCN(C1=O)c1ccc(cn1)-c1ccccc1 |w:15.16|
Structure
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