Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50231270 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_460575 (CHEMBL926651) |
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Ki | 8.1±n/a nM |
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Citation | Lee, YK; Parks, DJ; Lu, T; Thieu, TV; Markotan, T; Pan, W; McComsey, DF; Milkiewicz, KL; Crysler, CS; Ninan, N; Abad, MC; Giardino, EC; Maryanoff, BE; Damiano, BP; Player, MR 7-fluoroindazoles as potent and selective inhibitors of factor Xa. J Med Chem51:282-97 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50231270 |
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n/a |
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Name | BDBM50231270 |
Synonyms: | 1-(3-aminobenzo[d]isoxazol-5-yl)-6-(2'-dimethylaminomethyl-3-fluorobiphenyl-4-yl)-7-fluoro-1H-indazole-3-carboxylic acidamide | CHEMBL252341 |
Type | Small organic molecule |
Emp. Form. | C30H24F2N6O2 |
Mol. Mass. | 538.5474 |
SMILES | CN(C)Cc1ccccc1-c1ccc(c(F)c1)-c1ccc2c(nn(-c3ccc4onc(N)c4c3)c2c1F)C(N)=O |
Structure |
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