| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
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| Ligand | BDBM50231521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_460612 (CHEMBL927669) |
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| IC50 | 40000±n/a nM |
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| Citation |  Frederickson, M; Callaghan, O; Chessari, G; Congreve, M; Cowan, SR; Matthews, JE; McMenamin, R; Smith, DM; Vinkovic, M; Wallis, NG Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator. J Med Chem51:183-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urokinase-type plasminogen activator |
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| Name: | Urokinase-type plasminogen activator |
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| Synonyms: | 3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA |
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| Type: | Enzyme |
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| Mol. Mass.: | 48528.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00749 |
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| Residue: | 431 |
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| Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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| BDBM50231521 |
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| n/a |
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| Name | BDBM50231521 |
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| Synonyms: | 4-(2-aminoethoxy)-3,5-dichlorobenzoic acid | 4-[(2-amino)ethoxy]-3,5-dichlorobenzoic acid | CHEMBL401484 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H9Cl2NO3 |
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| Mol. Mass. | 250.079 |
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| SMILES | NCCOc1c(Cl)cc(cc1Cl)C(O)=O |
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| Structure | 
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