Found 192 hits with Last Name = 'smith' and Initial = 'dm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569664
(CHEMBL4859451)Show SMILES COc1ccccc1Nc1nc(Nc2cc3CN(C)CCc3cc2OC)ncc1C(N)=O | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.00500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569663
(CHEMBL4870155)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C(C)(F)F)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569665
(CHEMBL4864568)Show SMILES COCc1ccccc1Nc1nc(Nc2cc3CN(C)CCc3cc2OC)ncc1C(N)=O | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0370 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569667
(CHEMBL4848845)Show SMILES CO[C@@H](C)c1ccccc1Nc1nc(Nc2cc3CN(C)CCc3cc2OC)ncc1C(N)=O |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0370 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569669
(CHEMBL4866139)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2S(N)(=O)=O)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569672
(CHEMBL4865305)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2CO)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0610 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569666
(CHEMBL4855158)Show SMILES COC(C)c1ccccc1Nc1nc(Nc2cc3CN(C)CCc3cc2OC)ncc1C(N)=O | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0670 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569657
(CHEMBL4863492)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2Br)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 0.0940 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569661
(CHEMBL4872743)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C(F)(F)F)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569659
(CHEMBL4866616)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2Cl)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM552514
(2-((2-Methoxy-4-(4-methylpiperazine-1-carbonyl)phe...)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2c(F)cccc2F)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569671
(CHEMBL4860645)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C2CCCO2)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569660
(CHEMBL4849567)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569668
(CHEMBL4857184)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2N2CCOC2=O)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM552521
(WO2022098809, Example 4-8)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2c(F)cccc2C(F)(F)F)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569662
(CHEMBL4874375)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C(C)(C)C)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569656
(CHEMBL4871382)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(NC2CCCC2)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM552516
(WO2022098809, Example 4-3 | WO2022098809, Example ...)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2c(C)cccc2F)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569675
(CHEMBL4859773)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2c(F)cccc2CO)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569658
(CHEMBL4851277)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2F)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569670
(CHEMBL4868682)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C2CCCOC2)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM552551
(2-((6-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinol...)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559633
(CHEMBL4797075)Show SMILES COc1cccc(F)c1-c1cc2n(ncc2cn1)-c1cccc(n1)N1CC2CCC(C1)N2C | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559634
(CHEMBL4763655)Show SMILES COc1cccc(F)c1-c1cc2n(ncc2cn1)-c1cccc(n1)N1CC[C@@H](C1)N(C)C |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559649
(CHEMBL4778477)Show SMILES COc1cccc(F)c1-c1cc2n(ncc2cn1)-c1cc(Cl)cc(n1)N1CCN(C)CC1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559635
(CHEMBL4794486)Show SMILES [H][C@]12CN(c3cccc(n3)-n3ncc4cnc(cc34)-c3c(F)cccc3OC)[C@]([H])(CN1C)C2 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559632
(CHEMBL4795146)Show SMILES COc1cccc(F)c1-c1cc2n(ncc2cc1C#N)-c1cccc(n1)N1CCN(C)CC1 |(19.09,-7.98,;19.08,-9.52,;17.75,-10.28,;16.42,-9.51,;15.08,-10.28,;15.08,-11.84,;16.42,-12.59,;16.43,-14.13,;17.74,-11.82,;19.07,-12.59,;20.4,-11.82,;21.74,-12.59,;23.2,-12.1,;24.11,-13.34,;23.22,-14.6,;21.75,-14.13,;20.41,-14.91,;19.07,-14.14,;17.74,-14.91,;16.41,-15.67,;23.67,-10.64,;22.63,-9.51,;23.1,-8.05,;24.61,-7.71,;25.64,-8.85,;25.18,-10.32,;27.15,-8.52,;28.18,-9.67,;29.68,-9.35,;30.15,-7.89,;31.66,-7.56,;29.12,-6.74,;27.61,-7.07,)| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559636
(CHEMBL4760447)Show SMILES COc1cccc(F)c1-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCN(C)CC1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM24644
(4-N-(2,6-difluorobenzene)-3-N-(4-fluorophenyl)-1H-...)Show SMILES Fc1ccc(NC(=O)c2[nH]ncc2NC(=O)c2c(F)cccc2F)cc1 Show InChI InChI=1S/C17H11F3N4O2/c18-9-4-6-10(7-5-9)22-17(26)15-13(8-21-24-15)23-16(25)14-11(19)2-1-3-12(14)20/h1-8H,(H,21,24)(H,22,26)(H,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex
| Assay Description CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... |
J Med Chem 51: 4986-99 (2008)
Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50130009
((4S,15R,18S,21S,24S)-5-((S)-2-Acetylamino-hexanoyl...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O)C(N)=O Show InChI InChI=1S/C49H69N13O9/c1-3-4-17-35(56-29(2)63)43(66)61-39-27-41(64)53-22-11-10-19-34(42(50)65)57-46(69)38(26-31-28-55-33-18-9-8-16-32(31)33)59-44(67)36(20-12-23-54-49(51)52)58-45(68)37(25-30-14-6-5-7-15-30)60-47(70)40-21-13-24-62(40)48(39)71/h5-9,14-16,18,28,34-40,55H,3-4,10-13,17,19-27H2,1-2H3,(H2,50,65)(H,53,64)(H,56,63)(H,57,69)(H,58,68)(H,59,67)(H,60,70)(H,61,66)(H4,51,52,54)/t34-,35+,36+,37+,38-,39+,40+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligand |
Bioorg Med Chem Lett 13: 2337-40 (2003)
BindingDB Entry DOI: 10.7270/Q21G0MTZ |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559650
(CHEMBL4778314)Show SMILES COc1cccc(F)c1-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569678
(CHEMBL4878650)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(c(Nc2ccccc2)n1)C(F)(F)F | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559651
(CHEMBL4789558)Show SMILES COc1cccc(F)c1-c1cc2n(ncc2cn1)-c1ccnc(n1)N1CCN(C)CC1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50130014
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O |wD:4.3,(14.52,1.42,;13.19,.63,;13.2,-.91,;11.84,1.39,;10.51,.61,;10.53,-.94,;11.29,-2.27,;12.81,-2.27,;13.57,-3.59,;12.8,-4.92,;11.27,-4.91,;10.51,-3.59,;9.17,1.37,;9.15,2.91,;7.84,.58,;6.5,1.35,;6.48,2.89,;5.14,3.64,;5.13,5.18,;3.77,5.94,;2.46,5.16,;1.11,5.93,;2.46,3.62,;7.86,-.97,;7.09,-2.32,;5.36,-1.71,;4.19,-2.13,;4.94,-.77,;6.58,-1.39,;2.85,-1.36,;1.52,-2.13,;1.5,-3.67,;.17,-4.43,;-1.24,-3.8,;-2.28,-4.94,;-1.51,-6.27,;-1.99,-7.72,;-.97,-8.88,;.55,-8.57,;1.01,-7.11,;,-5.97,;2.85,.19,;1.52,.96,;4.19,.96,)| Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligand |
Bioorg Med Chem Lett 13: 2337-40 (2003)
BindingDB Entry DOI: 10.7270/Q21G0MTZ |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569677
(CHEMBL4860928) | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569674
(CHEMBL4873991)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2c(C)cccc2Br)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559668
(CHEMBL4745491)Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1n[nH]c2ccc(cc12)-c1cnn2CCCc12 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM24644
(4-N-(2,6-difluorobenzene)-3-N-(4-fluorophenyl)-1H-...)Show SMILES Fc1ccc(NC(=O)c2[nH]ncc2NC(=O)c2c(F)cccc2F)cc1 Show InChI InChI=1S/C17H11F3N4O2/c18-9-4-6-10(7-5-9)22-17(26)15-13(8-21-24-15)23-16(25)14-11(19)2-1-3-12(14)20/h1-8H,(H,21,24)(H,22,26)(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex
| Assay Description CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... |
J Med Chem 51: 4986-99 (2008)
Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559638
(CHEMBL4782526)Show SMILES CNC(=O)N1CCN(CC1)c1cccc(n1)-n1ncc2cnc(cc12)-c1c(F)cccc1OC | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50569673
(CHEMBL4856183)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C(C)(C)O)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM24646
(3-N-cyclohexyl-4-N-(2,6-difluorobenzene)-1H-pyrazo...)Show InChI InChI=1S/C17H18F2N4O2/c18-11-7-4-8-12(19)14(11)16(24)22-13-9-20-23-15(13)17(25)21-10-5-2-1-3-6-10/h4,7-10H,1-3,5-6H2,(H,20,23)(H,21,25)(H,22,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex
| Assay Description CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... |
J Med Chem 51: 4986-99 (2008)
Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559643
(CHEMBL4783731)Show SMILES COc1cccc(F)c1-c1cc2n(ncc2cn1)-c1cccc(n1)N1CC2(C1)CCCNC2 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM552515
(WO2022098809, Example 4-2)Show SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2c(C)cccc2C)n1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559667
(CHEMBL4746358)Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1n[nH]c2cnc(cc12)-c1cnn2CCCc12 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50559640
(CHEMBL4739893)Show SMILES CNC1CCN(CC1)c1cccc(n1)-n1ncc2cnc(cc12)-c1c(F)cccc1OC | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00672 BindingDB Entry DOI: 10.7270/Q28G8QD1 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM24654
(4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-...)Show SMILES Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 Show InChI InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex
| Assay Description CDK5/p35 activity was determined in DELFIA format using a biotinylated Histone H1 peptide. The phosphorylated peptide was quantified using rabbit pho... |
J Med Chem 51: 4986-99 (2008)
Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM24647
(4-N-(2,6-difluorobenzene)-3-N-(4-hydroxycyclohexyl...)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1[nH]ncc1NC(=O)c1c(F)cccc1F |r,wU:1.0,wD:4.7,(3.17,8.82,;2.37,7.51,;3.11,6.16,;2.31,4.84,;.77,4.87,;.03,6.22,;.83,7.54,;0,3.54,;-1.54,3.54,;-2.01,5,;-2.63,2.45,;-2.34,.94,;-3.7,.2,;-4.81,1.26,;-4.15,2.65,;-4.89,4,;-6.43,4.04,;-7.23,2.73,;-7.16,5.4,;-6.5,6.78,;-4.96,6.9,;-7.37,8.06,;-8.9,7.94,;-9.57,6.55,;-8.7,5.28,;-9.47,3.94,)| Show InChI InChI=1S/C17H18F2N4O3/c18-11-2-1-3-12(19)14(11)16(25)22-13-8-20-23-15(13)17(26)21-9-4-6-10(24)7-5-9/h1-3,8-10,24H,4-7H2,(H,20,23)(H,21,26)(H,22,25)/t9-,10- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex
| Assay Description CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... |
J Med Chem 51: 4986-99 (2008)
Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Urokinase-type plasminogen activator
(Homo sapiens (Human)) | BDBM50231520
((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)Show SMILES NC(=N)c1ccc(CNC(=O)[C@H](CO)NC(=O)[C@@H](CO)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C21H27N5O6S/c22-19(23)16-8-6-14(7-9-16)10-24-20(29)17(11-27)25-21(30)18(12-28)26-33(31,32)13-15-4-2-1-3-5-15/h1-9,17-18,26-28H,10-13H2,(H3,22,23)(H,24,29)(H,25,30)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex Therapeutics Ltd
Curated by ChEMBL
| Assay Description Inhibition of uPA |
J Med Chem 51: 183-6 (2008)
Article DOI: 10.1021/jm701359z BindingDB Entry DOI: 10.7270/Q2XG9QWK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50130009
((4S,15R,18S,21S,24S)-5-((S)-2-Acetylamino-hexanoyl...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O)C(N)=O Show InChI InChI=1S/C49H69N13O9/c1-3-4-17-35(56-29(2)63)43(66)61-39-27-41(64)53-22-11-10-19-34(42(50)65)57-46(69)38(26-31-28-55-33-18-9-8-16-32(31)33)59-44(67)36(20-12-23-54-49(51)52)58-45(68)37(25-30-14-6-5-7-15-30)60-47(70)40-21-13-24-62(40)48(39)71/h5-9,14-16,18,28,34-40,55H,3-4,10-13,17,19-27H2,1-2H3,(H2,50,65)(H,53,64)(H,56,63)(H,57,69)(H,58,68)(H,59,67)(H,60,70)(H,61,66)(H4,51,52,54)/t34-,35+,36+,37+,38-,39+,40+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand |
Bioorg Med Chem Lett 13: 2337-40 (2003)
BindingDB Entry DOI: 10.7270/Q21G0MTZ |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM24645
(3-N-(cyclopropylmethyl)-4-N-(2,6-difluorobenzene)-...)Show InChI InChI=1S/C15H14F2N4O2/c16-9-2-1-3-10(17)12(9)14(22)20-11-7-19-21-13(11)15(23)18-6-8-4-5-8/h1-3,7-8H,4-6H2,(H,18,23)(H,19,21)(H,20,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex
| Assay Description CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... |
J Med Chem 51: 4986-99 (2008)
Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W |
More data for this Ligand-Target Pair | 3D Structure (docked) |