| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Ligand | BDBM50569663 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2109901 (CHEMBL4818576) |
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| IC50 | 0.027000±n/a nM |
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| Citation |  Vara, BA; Levi, SM; Achab, A; Candito, DA; Fradera, X; Lesburg, CA; Kawamura, S; Lacey, BM; Lim, J; Methot, JL; Xu, Z; Xu, H; Smith, DM; Piesvaux, JA; Miller, JR; Bittinger, M; Ranganath, SH; Bennett, DJ; DiMauro, EF; Pasternak, A Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett12:653-661 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91316.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586597 |
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| Residue: | 833 |
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| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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| BDBM50569663 |
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| n/a |
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| Name | BDBM50569663 |
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| Synonyms: | CHEMBL4870155 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26F2N6O2 |
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| Mol. Mass. | 468.499 |
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| SMILES | COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C(C)(F)F)n1 |
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| Structure | 
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