| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
|---|
| Ligand | BDBM50231525 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_460612 (CHEMBL927669) |
|---|
| IC50 | 2700±n/a nM |
|---|
| Citation |  Frederickson, M; Callaghan, O; Chessari, G; Congreve, M; Cowan, SR; Matthews, JE; McMenamin, R; Smith, DM; Vinkovic, M; Wallis, NG Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator. J Med Chem51:183-6 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Urokinase-type plasminogen activator |
|---|
| Name: | Urokinase-type plasminogen activator |
|---|
| Synonyms: | 3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48528.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00749 |
|---|
| Residue: | 431 |
|---|
| Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
|
|
|
|---|
| BDBM50231525 |
|---|
| n/a |
|---|
| Name | BDBM50231525 |
|---|
| Synonyms: | CHEMBL253379 | N-[3-(isopropyloxy)phenyl] 4-[(2-amino)ethoxy]-3,5-dimethylbenzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H26N2O3 |
|---|
| Mol. Mass. | 342.432 |
|---|
| SMILES | CC(C)Oc1cccc(NC(=O)c2cc(C)c(OCCN)c(C)c2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
