| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50260287 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_506978 (CHEMBL938814) |
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| IC50 | 840±n/a nM |
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| Citation |  Patil, AD; Freyer, AJ; Killmer, L; Offen, P; Taylor, PB; Votta, BJ; Johnson, RK A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K. J Nat Prod65:624-7 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50260287 |
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| n/a |
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| Name | BDBM50260287 |
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| Synonyms: | CHEMBL494579 | cycloaltilisin 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26O5 |
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| Mol. Mass. | 406.4709 |
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| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#6]C1([#6])[#8]-c2cc(-[#8])c3-[#6](=O)-[#6]-[#6](-[#8]-c3c2-[#6]=[#6]1)-c1ccc(-[#8])cc1 |c:23| |
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| Structure | 
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