Reaction Details |
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Target | Thymidine phosphorylase |
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Ligand | BDBM50122764 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_511318 (CHEMBL996973) |
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IC50 | 20±n/a nM |
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Citation | Reigan, P; Gbaj, A; Stratford, IJ; Bryce, RA; Freeman, S Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors. Eur J Med Chem43:1248-60 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thymidine phosphorylase |
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Name: | Thymidine phosphorylase |
Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 49948.87 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
Residue: | 482 |
Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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BDBM50122764 |
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n/a |
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Name | BDBM50122764 |
Synonyms: | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylmethyl)-3H-imidazol-1-ium; chloride | 5-bromo-6-[(2-aminoimidazol-1-yl)methyl]uracil hydrochloride | CHEMBL122679 | CHEMBL65986 |
Type | Small organic molecule |
Emp. Form. | C8H9BrN5O2 |
Mol. Mass. | 287.093 |
SMILES | Nc1[nH+]ccn1Cc1[nH]c(=O)[nH]c(=O)c1Br |
Structure |
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