Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM50121753 (1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against human thymidine phosphorylase | Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM20079 (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against thymidine phosphorylase | J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM20079 (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Manchester Curated by ChEMBL | Assay Description Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assay | Eur J Med Chem 43: 1248-60 (2008) Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thymidine phosphorylase (Escherichia coli) | BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione | 6-Amino-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli thymidine phosphorylase | J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione | 6-Amino-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli thymidine phosphorylase | Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase/oxidase (Bos taurus (Bovine)) | BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Manchester Curated by ChEMBL | Assay Description Inhibition of bovine xanthine oxidase using hypoxanthine as a substrate | Eur J Med Chem 43: 1248-60 (2008) Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase/oxidase (Bos taurus (Bovine)) | BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Manchester Curated by ChEMBL | Assay Description Inhibition of bovine xanthine oxidase using xanthine as a substrate | Eur J Med Chem 43: 1248-60 (2008) Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trans-sialidase (Trypanosoma cruzi) | BDBM50118216 ((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi trans-Sialidase | Bioorg Med Chem Lett 19: 589-96 (2009) Article DOI: 10.1016/j.bmcl.2008.12.065 BindingDB Entry DOI: 10.7270/Q2X92C7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trans-sialidase (Trypanosoma cruzi) | BDBM4706 ((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.23E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi trans-Sialidase | Bioorg Med Chem Lett 19: 589-96 (2009) Article DOI: 10.1016/j.bmcl.2008.12.065 BindingDB Entry DOI: 10.7270/Q2X92C7J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM50134398 (1-methyl-2,5-dioxo-4-pentylimidazolidine-4-carbald...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 1.25E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli phosphorylase | Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM50134398 (1-methyl-2,5-dioxo-4-pentylimidazolidine-4-carbald...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.50E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli thymidine phosphorylase | Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine phosphorylase (Mus musculus) | BDBM50134397 (5-Methyl-1H-pyrimidine-2,4-dione | CHEMBL993 | THY...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 3.47E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against mouse liver thymidine phosphorylase at 0.15 mM thymidine substrate | Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35536 (symmetric dicoumarol analogue, 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35534 (symmetric dicoumarol analogue, 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35537 (symmetric dicoumarol analogue, 13) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35544 (4-hydroxy-2H-chromen-2-one core, 20) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35541 (4-hydroxy-2H-chromen-2-one core, 17) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35525 (3,3''''-methylenebis(4-hydroxy-coumarin | 3,3''''-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid UniChem Similars | DrugBank MMDB Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35527 (symmetric dicoumarol analogue, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35531 (symmetric dicoumarol analogue, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35530 (symmetric dicoumarol analogue, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35533 (symmetric dicoumarol analogue, 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM50055714 (3-(4,7-dihydroxy-2-oxo-2H-3-chromenylmethyl)-4,7-d...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO1 | J Med Chem 50: 6316-25 (2007) Article DOI: 10.1021/jm070472p BindingDB Entry DOI: 10.7270/Q2DV1JM1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35525 (3,3''''-methylenebis(4-hydroxy-coumarin | 3,3''''-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid UniChem Similars | DrugBank MMDB Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO1 | J Med Chem 50: 6316-25 (2007) Article DOI: 10.1021/jm070472p BindingDB Entry DOI: 10.7270/Q2DV1JM1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35529 (symmetric dicoumarol analogue, 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50317140 (5-(2-(diethylamino)ethylamino)-7-hydroxy-8,9-dimet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
the University of Manchester and Manchester Cancer Research Center Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry | Bioorg Med Chem Lett 20: 2832-6 (2010) Article DOI: 10.1016/j.bmcl.2010.03.051 BindingDB Entry DOI: 10.7270/Q2FB533K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35547 (4-hydroxy-2H-chromen-2-one core, 23) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35543 (4-hydroxy-2H-chromen-2-one core, 19) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35546 (4-hydroxy-2H-chromen-2-one core, 22) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35540 (4-hydroxy-2H-chromen-2-one core, 16) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50008356 (5-(2-(diethylamino)ethylamino)-8-methoxy-1-methyl-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
the University of Manchester and Manchester Cancer Research Center Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry | Bioorg Med Chem Lett 20: 2832-6 (2010) Article DOI: 10.1016/j.bmcl.2010.03.051 BindingDB Entry DOI: 10.7270/Q2FB533K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35532 (symmetric dicoumarol analogue, 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35552 (4-hydroxy-2H-chromen-2-one core, 29) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50515994 (CHEMBL4514167) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometry | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111649 BindingDB Entry DOI: 10.7270/Q2FT8QCK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35528 (symmetric dicoumarol analogue, 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50515978 (CHEMBL1967497) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometry | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111649 BindingDB Entry DOI: 10.7270/Q2FT8QCK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50354527 (CHEMBL1836819) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry | J Med Chem 54: 6597-611 (2011) Article DOI: 10.1021/jm200416e BindingDB Entry DOI: 10.7270/Q21Z44TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35526 (symmetric dicoumarol analogue, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35550 (4-hydroxy-2H-chromen-2-one core, 26) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50150962 (CHEMBL3770366) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSA | Eur J Med Chem 111: 33-45 (2016) Article DOI: 10.1016/j.ejmech.2016.01.022 BindingDB Entry DOI: 10.7270/Q2MG7RCQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50150963 (CHEMBL3770674) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSA | Eur J Med Chem 111: 33-45 (2016) Article DOI: 10.1016/j.ejmech.2016.01.022 BindingDB Entry DOI: 10.7270/Q2MG7RCQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD(P)H dehydrogenase [quinone] 1 (Homo sapiens (Human)) | BDBM35548 (4-hydroxy-2H-chromen-2-one core, 24) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Manchester | Assay Description Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa... | J Med Chem 52: 7142-56 (2009) Article DOI: 10.1021/jm9011609 BindingDB Entry DOI: 10.7270/Q2222S40 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50515995 (CHEMBL4435240) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometry | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111649 BindingDB Entry DOI: 10.7270/Q2FT8QCK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50008344 (5-(2-(diethylamino)ethylamino)-8-hydroxy-1-methyl-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
the University of Manchester and Manchester Cancer Research Center Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry | Bioorg Med Chem Lett 20: 2832-6 (2010) Article DOI: 10.1016/j.bmcl.2010.03.051 BindingDB Entry DOI: 10.7270/Q2FB533K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50317138 (5-(2-(diethylamino)ethylamino)-7,10-dimethoxy-6H-i...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
the University of Manchester and Manchester Cancer Research Center Curated by ChEMBL | Assay Description Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry | Bioorg Med Chem Lett 20: 2832-6 (2010) Article DOI: 10.1016/j.bmcl.2010.03.051 BindingDB Entry DOI: 10.7270/Q2FB533K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human)) | BDBM50515985 (CHEMBL1237241 | TCMDC-142036) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometry | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111649 BindingDB Entry DOI: 10.7270/Q2FT8QCK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM50122764 (2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli thymidine phosphorylase | Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM50122764 (2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory concentration against human thymidine phosphorylase | J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM50121753 (1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli thymidine phosphorylase | Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine phosphorylase (Homo sapiens (Human)) | BDBM50122764 (2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Manchester Curated by ChEMBL | Assay Description Inhibition of human recombinant thymidine phosphorylase | Eur J Med Chem 43: 1248-60 (2008) Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP | |||||||||||
More data for this Ligand-Target Pair |
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