Reaction Details |
| Report a problem with these data |
Target | Thymidine phosphorylase |
---|
Ligand | BDBM50122764 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_208373 (CHEMBL813681) |
---|
IC50 | 19±n/a nM |
---|
Citation | McNally, VA; Gbaj, A; Douglas, KT; Stratford, IJ; Jaffar, M; Freeman, S; Bryce, RA Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening. Bioorg Med Chem Lett13:3705-9 (2003) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thymidine phosphorylase |
---|
Name: | Thymidine phosphorylase |
Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 49948.87 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
Residue: | 482 |
Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
|
|
|
BDBM50122764 |
---|
n/a |
---|
Name | BDBM50122764 |
Synonyms: | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylmethyl)-3H-imidazol-1-ium; chloride | 5-bromo-6-[(2-aminoimidazol-1-yl)methyl]uracil hydrochloride | CHEMBL122679 | CHEMBL65986 |
Type | Small organic molecule |
Emp. Form. | C8H9BrN5O2 |
Mol. Mass. | 287.093 |
SMILES | Nc1[nH+]ccn1Cc1[nH]c(=O)[nH]c(=O)c1Br |
Structure |
|