Reaction Details |
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Target | Pyruvate kinase |
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Ligand | BDBM50270349 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_530311 (CHEMBL980373) |
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IC50 | 1500000±n/a nM |
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Citation | Nowicki, MW; Tulloch, LB; Worralll, L; McNae, IW; Hannaert, V; Michels, PA; Fothergill-Gilmore, LA; Walkinshaw, MD; Turner, NJ Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem16:5050-61 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Pyruvate kinase |
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Name: | Pyruvate kinase |
Synonyms: | KPYK_LEIME | PYK |
Type: | PROTEIN |
Mol. Mass.: | 54404.51 |
Organism: | Leishmania mexicana |
Description: | ChEMBL_530311 |
Residue: | 499 |
Sequence: | MSQLAHNLTLSIFDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEY
HQTTINNVRQAAAELGVNIAIALDTKGPEIRTGQFVGGDAVMERGATCYVTTDPAFADKG
TKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNL
PGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGDVRKALGPKGRDIMIICKI
ENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQML
ESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSALNE
YVFFNSIKKLQHIPMSADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIV
CVTTRLQTCRQLNITQGVESVFFDADKLGHDEGKEHRVAAGVEFAKSKGYVQTGDYCVVI
HADHKVKGYANQTRILLVE
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BDBM50270349 |
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n/a |
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Name | BDBM50270349 |
Synonyms: | (2R,3S,4S,5R)-2-(hydroxymethyl)-5-(((R)-1-(naphthalen-2-yl)ethylamino)methyl)-tetrahydrofuran-3,4-diol | CHEMBL477108 |
Type | Small organic molecule |
Emp. Form. | C18H23NO4 |
Mol. Mass. | 317.3795 |
SMILES | C[C@@H](NC[C@H]1O[C@H](CO)[C@@H](O)[C@@H]1O)c1ccc2ccccc2c1 |r| |
Structure |
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