Reaction Details |
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Target | Egl nine homolog 1 |
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Ligand | BDBM50251999 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_488018 (CHEMBL983035) |
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IC50 | >40000±n/a nM |
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Citation | Tegley, CM; Viswanadhan, VN; Biswas, K; Frohn, MJ; Peterkin, TA; Chang, C; Bürli, RW; Dao, JH; Veith, H; Rogers, N; Yoder, SC; Biddlecome, G; Tagari, P; Allen, JR; Hungate, RW Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation. Bioorg Med Chem Lett18:3925-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Egl nine homolog 1 |
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Name: | Egl nine homolog 1 |
Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
Type: | Protein |
Mol. Mass.: | 46035.59 |
Organism: | Homo sapiens (Human) |
Description: | Q9GZT9 |
Residue: | 426 |
Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
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BDBM50251999 |
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n/a |
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Name | BDBM50251999 |
Synonyms: | 2-(3-hydroxy-2-(3-phenylpropanamido)-2,3-dihydrothiazol-4-yl)acetic acid | CHEMBL481168 |
Type | Small organic molecule |
Emp. Form. | C14H14N2O4S |
Mol. Mass. | 306.337 |
SMILES | OC(=O)Cc1csc(=NC(=O)CCc2ccccc2)n1O |w:8.8| |
Structure |
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