Found 186 hits with Last Name = 'dao' and Initial = 'jh' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50264220
(2-(1,6-diphenyl-1H-imidazo[4,5-c]pyridine-4-carbox...)Show SMILES OC(=O)CNC(=O)c1nc(cc2n(cnc12)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C21H16N4O3/c26-18(27)12-22-21(28)20-19-17(11-16(24-20)14-7-3-1-4-8-14)25(13-23-19)15-9-5-2-6-10-15/h1-11,13H,12H2,(H,22,28)(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysis |
Bioorg Med Chem Lett 18: 5023-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.012
BindingDB Entry DOI: 10.7270/Q2ZS2WB7 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251959
(2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-h...)Show SMILES CC(C)(C)c1ccc(CS(=O)(=O)CC(=O)N=c2scc(CC(O)=O)n2O)cc1 |w:15.14| Show InChI InChI=1S/C18H22N2O6S2/c1-18(2,3)13-6-4-12(5-7-13)10-28(25,26)11-15(21)19-17-20(24)14(9-27-17)8-16(22)23/h4-7,9,24H,8,10-11H2,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016165
(CHEMBL3261516)Show SMILES Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1 Show InChI InChI=1S/C15H12ClN5OS/c1-7-2-3-8(9(16)6-7)11-12(13(17)22)23-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016166
(CHEMBL3261517)Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1 Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 2 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 1 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251958
(2-(2-(2-(benzylsulfonyl)acetamido)-3-hydroxy-2,3-d...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)Cc2ccccc2)n1O |w:8.8| Show InChI InChI=1S/C14H14N2O6S2/c17-12(9-24(21,22)8-10-4-2-1-3-5-10)15-14-16(20)11(7-23-14)6-13(18)19/h1-5,7,20H,6,8-9H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 6 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.667 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016148
(CHEMBL3261500)Show InChI InChI=1S/C15H9Cl2N3OS/c16-9-1-2-10(11(17)7-9)12-13(14(18)21)22-15(20-12)8-3-5-19-6-4-8/h1-7H,(H2,18,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.012 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016161
(CHEMBL3261512)Show SMILES NC(=O)c1sc(nc1-c1ccccc1C(F)(F)F)-c1ccnc(N)n1 Show InChI InChI=1S/C15H10F3N5OS/c16-15(17,18)8-4-2-1-3-7(8)10-11(12(19)24)25-13(23-10)9-5-6-21-14(20)22-9/h1-6H,(H2,19,24)(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016160
(CHEMBL3261511)Show InChI InChI=1S/C14H10FN5OS/c15-8-4-2-1-3-7(8)10-11(12(16)21)22-13(20-10)9-5-6-18-14(17)19-9/h1-6H,(H2,16,21)(H2,17,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 9 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.333 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251957
(CHEMBL519615 | {2-[2-(Biphenyl-4-sulfonyl)-acetyli...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccc(cc2)-c2ccccc2)n1O |w:8.8| Show InChI InChI=1S/C19H16N2O6S2/c22-17(20-19-21(25)15(11-28-19)10-18(23)24)12-29(26,27)16-8-6-14(7-9-16)13-4-2-1-3-5-13/h1-9,11,25H,10,12H2,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016167
(CHEMBL3261518)Show InChI InChI=1S/C10H12N6OS/c1-16(2)8-6(7(11)17)18-9(15-8)5-3-4-13-10(12)14-5/h3-4H,1-2H3,(H2,11,17)(H2,12,13,14) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50252002
(2-(2-(2-(4-tert-butylphenylsulfonyl)acetamido)-3-h...)Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)CC(=O)N=c1scc(CC(O)=O)n1O |w:16.16| Show InChI InChI=1S/C17H20N2O6S2/c1-17(2,3)11-4-6-13(7-5-11)27(24,25)10-14(20)18-16-19(23)12(9-26-16)8-15(21)22/h4-7,9,23H,8,10H2,1-3H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 18 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251908
(2-(3-hydroxy-2-(2-(naphthalen-2-ylsulfonyl)acetami...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccc3ccccc3c2)n1O |w:8.8| Show InChI InChI=1S/C17H14N2O6S2/c20-15(18-17-19(23)13(9-26-17)8-16(21)22)10-27(24,25)14-6-5-11-3-1-2-4-12(11)7-14/h1-7,9,23H,8,10H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.111 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016162
(CHEMBL3261513)Show InChI InChI=1S/C14H9F2N5OS/c15-6-1-2-8(16)7(5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251907
(2-(2-(2-(4-chlorophenylsulfonyl)acetamido)-3-hydro...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccc(Cl)cc2)n1O |w:8.8| Show InChI InChI=1S/C13H11ClN2O6S2/c14-8-1-3-10(4-2-8)24(21,22)7-11(17)15-13-16(20)9(6-23-13)5-12(18)19/h1-4,6,20H,5,7H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.222 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.025 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016153
(CHEMBL3261505)Show InChI InChI=1S/C10H10N4O3S/c1-2-17-9(16)6-7(15)14-8(18-6)5-3-4-12-10(11)13-5/h3-4,15H,2H2,1H3,(H2,11,12,13) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 27 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50252001
(2-(3-hydroxy-2-(2-tosylacetamido)-2,3-dihydrothiaz...)Show SMILES Cc1ccc(cc1)S(=O)(=O)CC(=O)N=c1scc(CC(O)=O)n1O |w:13.13| Show InChI InChI=1S/C14H14N2O6S2/c1-9-2-4-11(5-3-9)24(21,22)8-12(17)15-14-16(20)10(7-23-14)6-13(18)19/h2-5,7,20H,6,8H2,1H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016164
(CHEMBL3261515)Show SMILES NC(=O)c1sc(nc1-c1cc(Cl)cc(Cl)c1)-c1ccnc(N)n1 Show InChI InChI=1S/C14H9Cl2N5OS/c15-7-3-6(4-8(16)5-7)10-11(12(17)22)23-13(21-10)9-1-2-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.037 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.074 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50264219
(2-(6-chloro-1-phenyl-1H-imidazo[4,5-c]pyridine-4-c...)Show InChI InChI=1S/C15H11ClN4O3/c16-11-6-10-13(14(19-11)15(23)17-7-12(21)22)18-8-20(10)9-4-2-1-3-5-9/h1-6,8H,7H2,(H,17,23)(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysis |
Bioorg Med Chem Lett 18: 5023-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.012
BindingDB Entry DOI: 10.7270/Q2ZS2WB7 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251900
(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccccc2)n1O |w:8.8| Show InChI InChI=1S/C13H12N2O6S2/c16-11(8-23(20,21)10-4-2-1-3-5-10)14-13-15(19)9(7-22-13)6-12(17)18/h1-5,7,19H,6,8H2,(H,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251905
(2-(2-(2-(2-chlorophenylsulfonyl)acetamido)-3-hydro...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccccc2Cl)n1O |w:8.8| Show InChI InChI=1S/C13H11ClN2O6S2/c14-9-3-1-2-4-10(9)24(21,22)7-11(17)15-13-16(20)8(6-23-13)5-12(18)19/h1-4,6,20H,5,7H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CK1delta (unknown origin) by TR-FRET assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016163
(CHEMBL3261514)Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 54 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016147
(CHEMBL3261499)Show InChI InChI=1S/C10H9N3O2S/c1-15-9-7(8(11)14)16-10(13-9)6-2-4-12-5-3-6/h2-5H,1H3,(H2,11,14) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251906
(2-(2-(2-(3-chlorophenylsulfonyl)acetamido)-3-hydro...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2cccc(Cl)c2)n1O |w:8.8| Show InChI InChI=1S/C13H11ClN2O6S2/c14-8-2-1-3-10(4-8)24(21,22)7-11(17)15-13-16(20)9(6-23-13)5-12(18)19/h1-4,6,20H,5,7H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016137
(CHEMBL3261489)Show InChI InChI=1S/C15H11N3OS/c16-14(19)13-12(10-4-2-1-3-5-10)18-15(20-13)11-6-8-17-9-7-11/h1-9H,(H2,16,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50016166
(CHEMBL3261517)Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1 Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20) | PDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CK1delta (unknown origin) by TR-FRET assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016146
(CHEMBL3261498)Show InChI InChI=1S/C15H10N4OS/c20-14-12-13(17-10-3-1-2-4-11(10)18-14)19-15(21-12)9-5-7-16-8-6-9/h1-8,17H,(H,18,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016136
(CHEMBL3261488)Show InChI InChI=1S/C9H7N3O2S/c10-7(13)6-8(14)12-9(15-6)5-1-3-11-4-2-5/h1-4,14H,(H2,10,13) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016135
(CHEMBL3261245)Show InChI InChI=1S/C15H10N2O2S/c18-15(19)13-12(10-4-2-1-3-5-10)17-14(20-13)11-6-8-16-9-7-11/h1-9H,(H,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 172 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50264174
(2-(1-phenyl-1H-imidazo[4,5-c]pyridine-4-carboxamid...)Show InChI InChI=1S/C15H12N4O3/c20-12(21)8-17-15(22)14-13-11(6-7-16-14)19(9-18-13)10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,22)(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysis |
Bioorg Med Chem Lett 18: 5023-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.012
BindingDB Entry DOI: 10.7270/Q2ZS2WB7 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016116
(CHEMBL3261228)Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.023 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016116
(CHEMBL3261228)Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.75 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016116
(CHEMBL3261228)Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 318 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 1.5 uM of ATP as substrate by AlphaScreen assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50264175
(2-(1-benzyl-1H-imidazo[4,5-c]pyridine-4-carboxamid...)Show InChI InChI=1S/C16H14N4O3/c21-13(22)8-18-16(23)15-14-12(6-7-17-15)20(10-19-14)9-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,18,23)(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysis |
Bioorg Med Chem Lett 18: 5023-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.012
BindingDB Entry DOI: 10.7270/Q2ZS2WB7 |
More data for this
Ligand-Target Pair | |
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM50016116
(CHEMBL3261228)Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 323 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay |
Eur J Med Chem 80: 364-82 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8 |
More data for this
Ligand-Target Pair | |
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