Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50251385 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_488137 (CHEMBL987428) |
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IC50 | 28±n/a nM |
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Citation | Ye, B; Bauman, J; Chen, M; Davey, D; Khim, SK; King, B; Kirkland, T; Kochanny, M; Liang, A; Lentz, D; May, K; Mendoza, L; Phillips, G; Selchau, V; Schlyer, S; Tseng, JL; Wei, RG; Ye, H; Parkinson, J; Guilford, WJ Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett18:3891-4 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM50251385 |
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n/a |
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Name | BDBM50251385 |
Synonyms: | 5-((methyl(3-(methyl(2-oxo-2-(4-phenoxyphenylamino)ethyl)amino)propyl)amino)methyl)furan-2-carboxylic acid | CHEMBL519094 |
Type | Small organic molecule |
Emp. Form. | C25H29N3O5 |
Mol. Mass. | 451.5149 |
SMILES | CN(CCCN(C)Cc1ccc(o1)C(O)=O)CC(=O)Nc1ccc(Oc2ccccc2)cc1 |
Structure |
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