| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
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| Ligand | BDBM50251795 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_488138 (CHEMBL987429) |
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| IC50 | 350±n/a nM |
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| Citation |  Ye, B; Bauman, J; Chen, M; Davey, D; Khim, SK; King, B; Kirkland, T; Kochanny, M; Liang, A; Lentz, D; May, K; Mendoza, L; Phillips, G; Selchau, V; Schlyer, S; Tseng, JL; Wei, RG; Ye, H; Parkinson, J; Guilford, WJ Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett18:3891-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukotriene A-4 hydrolase |
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| Name: | Leukotriene A-4 hydrolase |
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| Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
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| Type: | Hydrolase; metalloprotease |
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| Mol. Mass.: | 69280.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant LTA4H. |
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| Residue: | 611 |
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| Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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| BDBM50251795 |
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| n/a |
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| Name | BDBM50251795 |
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| Synonyms: | 2-((3-(benzyl(methyl)amino)propyl)(methyl)amino)-N-(4-phenoxyphenyl)acetamide | CHEMBL480985 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H31N3O2 |
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| Mol. Mass. | 417.5432 |
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| SMILES | CN(CCCN(C)Cc1ccccc1)CC(=O)Nc1ccc(Oc2ccccc2)cc1 |
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| Structure | 
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