Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM10514 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_489450 (CHEMBL982932) |
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IC50 | 21.5±n/a nM |
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Citation | Rosini, M; Simoni, E; Bartolini, M; Cavalli, A; Ceccarini, L; Pascu, N; McClymont, DW; Tarozzi, A; Bolognesi, ML; Minarini, A; Tumiatti, V; Andrisano, V; Mellor, IR; Melchiorre, C Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush. J Med Chem51:4381-4 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
Type: | Enzyme |
Mol. Mass.: | 67792.70 |
Organism: | Homo sapiens (Human) |
Description: | P22303 |
Residue: | 614 |
Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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BDBM10514 |
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n/a |
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Name | BDBM10514 |
Synonyms: | CHEMBL191758 | N-(3-aminopropyl)-6-chloro-1,2,3,4-tetrahydroacridin-9-amine | N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine | tacrine (TC) deriv. 15 |
Type | Small organic molecule |
Emp. Form. | C16H20ClN3 |
Mol. Mass. | 289.803 |
SMILES | NCCCNc1c2CCCCc2nc2cc(Cl)ccc12 |
Structure |
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