Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50272199 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_510221 (CHEMBL1004837) |
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IC50 | 840±n/a nM |
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Citation | Enomoto, H; Morikawa, Y; Miyake, Y; Tsuji, F; Mizuchi, M; Suhara, H; Fujimura, K; Horiuchi, M; Ban, M Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett18:4529-32 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_CAVPO | LTA4H |
Type: | PROTEIN |
Mol. Mass.: | 68972.78 |
Organism: | Cavia porcellus |
Description: | ChEMBL_544515 |
Residue: | 611 |
Sequence: | MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDL
TIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAP
DPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETES
MLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
TWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGET
QAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSI
TTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVT
AMLVGKDLKVE
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BDBM50272199 |
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n/a |
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Name | BDBM50272199 |
Synonyms: | (2S,5S)-1-((S)-3-Mercapto-2-methyl-propionyl)-5-(2-methyl-benzylsulfanyl)-pyrrolidine-2-carboxylic acid | CHEMBL500408 |
Type | Small organic molecule |
Emp. Form. | C17H23NO3S2 |
Mol. Mass. | 353.499 |
SMILES | C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCc1ccccc1C |r| |
Structure |
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