| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
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| Ligand | BDBM50245034 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_512157 (CHEMBL980951) |
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| IC50 | 820±n/a nM |
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| Citation |  Yokoyama, K; Ishikawa, N; Igarashi, S; Kawano, N; Masuda, N; Hattori, K; Miyazaki, T; Ogino, S; Orita, M; Matsumoto, Y; Takeuchi, M; Ohta, M Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines. Bioorg Med Chem16:7968-74 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 4 |
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| Name: | C-C chemokine receptor type 4 |
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| Synonyms: | C-C CKR-4 | CC-CKR-4 | CCR-4 | CCR4_MOUSE | CD_antigen=CD194 | Ccr4 | Cmkbr4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41410.76 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_512157 |
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| Residue: | 360 |
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| Sequence: | MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVV
VLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVG
FYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYT
EHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRA
VRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLN
PVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
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| BDBM50245034 |
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| n/a |
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| Name | BDBM50245034 |
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| Synonyms: | CHEMBL488018 | N-(3,4-Difluorophenyl)-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29F2N5O2 |
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| Mol. Mass. | 469.5269 |
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| SMILES | COc1cc2nc(nc(Nc3ccc(F)c(F)c3)c2cc1OC)N1CCC(CC1)N1CCCC1 |
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| Structure | 
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