| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50292630 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535143 (CHEMBL984593) |
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| Ki | 2±n/a nM |
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| Citation |  Chiellini, G; Grzywacz, P; Plum, LA; Barycki, R; Clagett-Dame, M; DeLuca, HF Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists. Bioorg Med Chem16:8563-73 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | Nr1i1 | VDR_RAT | Vdr | Vitamin D receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47811.07 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1505946 |
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| Residue: | 423 |
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| Sequence: | MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSL
RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSS
SSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGF
AKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAG
HTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQ
TYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
EIS
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| BDBM50292630 |
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| n/a |
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| Name | BDBM50292630 |
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| Synonyms: | (23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxyvitaminD3-26,23-lactone | (5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methylene-9,10-secoestra-5,7-dien-17-yl]propyl}-3-methylenedihydro-2(3H)-furanone | CHEMBL261197 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H38O4 |
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| Mol. Mass. | 426.5882 |
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| SMILES | [#6]-[#6@H](-[#6]-[#6@@H]-1-[#6]-[#6](=[#6])-[#6](=O)-[#8]-1)-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| |
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| Structure | 
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