Reaction Details |
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Target | Prostasin |
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Ligand | BDBM50246997 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_557785 (CHEMBL953294) |
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Ki | 27±n/a nM |
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Citation | Tully, DC; Vidal, A; Chatterjee, AK; Williams, JA; Roberts, MJ; Petrassi, HM; Spraggon, G; Bursulaya, B; Pacoma, R; Shipway, A; Schumacher, AM; Danahay, H; Harris, JL Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg Med Chem Lett18:5895-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostasin |
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Name: | Prostasin |
Synonyms: | PRSS8 | PRSS8_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 36426.48 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_557785 |
Residue: | 343 |
Sequence: | MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQV
SITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDI
IPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSV
SLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGG
PLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQ
PDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
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BDBM50246997 |
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n/a |
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Name | BDBM50246997 |
Synonyms: | CHEMBL505738 | benzyl (R)-1-((2S,4R)-2-(((S)-6-amino-1-(benzo[d]oxazol-2-yl)-1-oxohexan-2-yl)carbamoyl)-4-(4-fluorobenzyloxy)pyrrolidin-1-yl)-1-oxo-4-phenylbutan-2-ylcarbamate |
Type | Small organic molecule |
Emp. Form. | C43H46FN5O7 |
Mol. Mass. | 763.853 |
SMILES | NCCCC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](CCc1ccccc1)NC(=O)OCc1ccccc1)OCc1ccc(F)cc1)C(=O)c1nc2ccccc2o1 |r| |
Structure |
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