| Reaction Details |
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 | Report a problem with these data |
| Target | Prostasin |
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| Ligand | BDBM50246999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_557785 (CHEMBL953294) |
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| Ki | 19±n/a nM |
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| Citation |  Tully, DC; Vidal, A; Chatterjee, AK; Williams, JA; Roberts, MJ; Petrassi, HM; Spraggon, G; Bursulaya, B; Pacoma, R; Shipway, A; Schumacher, AM; Danahay, H; Harris, JL Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg Med Chem Lett18:5895-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostasin |
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| Name: | Prostasin |
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| Synonyms: | PRSS8 | PRSS8_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36426.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_557785 |
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| Residue: | 343 |
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| Sequence: | MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQV
SITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDI
IPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSV
SLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGG
PLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQ
PDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
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| BDBM50246999 |
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| n/a |
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| Name | BDBM50246999 |
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| Synonyms: | CHEMBL500474 | benzyl (R)-1-((2S,4R)-2-(((S)-6-amino-1-(benzo[d]oxazol-2-yl)-1-oxohexan-2-yl)carbamoyl)-4-(cyclohexylmethoxy)pyrrolidin-1-yl)-1-oxo-4-phenylbutan-2-ylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C43H53N5O7 |
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| Mol. Mass. | 751.9102 |
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| SMILES | NCCCC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](CCc1ccccc1)NC(=O)OCc1ccccc1)OCC1CCCCC1)C(=O)c1nc2ccccc2o1 |r| |
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| Structure | 
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