| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 1 |
|---|
| Ligand | BDBM50265099 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_496465 (CHEMBL1007112) |
|---|
| EC50 | 20±n/a nM |
|---|
| Citation |  Pinard, E; Alberati, D; Borroni, E; Fischer, H; Hainzl, D; Jolidon, S; Moreau, JL; Narquizian, R; Nettekoven, M; Norcross, RD; Stalder, H; Thomas, AW Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors. Bioorg Med Chem Lett18:5134-9 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent glycine transporter 1 |
|---|
| Name: | Sodium- and chloride-dependent glycine transporter 1 |
|---|
| Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 78270.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P48067 |
|---|
| Residue: | 706 |
|---|
| Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
|
|
|
|---|
| BDBM50265099 |
|---|
| n/a |
|---|
| Name | BDBM50265099 |
|---|
| Synonyms: | 3-fluoro-4-(4-(4-(methylsulfonyl)biphenylcarbonyl)piperazin-1-yl)benzonitrile | CHEMBL496966 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22FN3O3S |
|---|
| Mol. Mass. | 463.524 |
|---|
| SMILES | CS(=O)(=O)c1ccc(-c2ccccc2)c(c1)C(=O)N1CCN(CC1)c1ccc(cc1F)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
