| Reaction Details |
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 | Report a problem with these data |
| Target | Egl nine homolog 1 |
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| Ligand | BDBM50264221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535338 (CHEMBL983464) |
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| IC50 | 1400±n/a nM |
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| Citation |  Frohn, M; Viswanadhan, V; Pickrell, AJ; Golden, JE; Muller, KM; Bürli, RW; Biddlecome, G; Yoder, SC; Rogers, N; Dao, JH; Hungate, R; Allen, JR Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors. Bioorg Med Chem Lett18:5023-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Egl nine homolog 1 |
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| Name: | Egl nine homolog 1 |
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| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
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| Type: | Protein |
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| Mol. Mass.: | 46035.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9GZT9 |
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| Residue: | 426 |
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| Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
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| BDBM50264221 |
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| n/a |
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| Name | BDBM50264221 |
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| Synonyms: | 2-(4-hydroxy-8-iodoisoquinoline-3-carboxamido)acetic acid | CHEMBL509064 | N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9IN2O4 |
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| Mol. Mass. | 372.1153 |
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| SMILES | OC(=O)CNC(=O)c1ncc2c(I)cccc2c1O |
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| Structure | 
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