Reaction Details |
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Target | Melanocortin receptor 3 |
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Ligand | BDBM50253748 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_538607 (CHEMBL1027397) |
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Ki | 155±n/a nM |
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Citation | Tian, X; Switzer, AG; Derose, SA; Mishra, RK; Solinsky, MG; Mumin, RN; Ebetino, FH; Jayasinghe, LR; Webster, ME; Colson, AO; Crossdoersen, D; Pinney, BB; Farmer, JA; Dowty, ME; Obringer, CM; Cruze, CA; Burklow, ML; Suchanek, PM; Dong, L; Dirr, MK; Sheldon, RJ; Wos, JA Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents. J Med Chem51:6055-66 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanocortin receptor 3 |
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Name: | Melanocortin receptor 3 |
Synonyms: | MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4) |
Type: | Enzyme |
Mol. Mass.: | 36044.86 |
Organism: | Homo sapiens (Human) |
Description: | P41968 |
Residue: | 323 |
Sequence: | MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
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BDBM50253748 |
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n/a |
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Name | BDBM50253748 |
Synonyms: | (2S)-N-((1R)-1-[(4-Fluorophenyl)methyl]-2-{(2S)-4-[(1S)-2-(methylamino)-1-(2-naphthalenylmethyl)-2-oxoethyl]-3-oxo-2-propyl-1-piperazinyl}-2-oxoethyl)-2-piperidinecarboxamide | CHEMBL448410 |
Type | Small organic molecule |
Emp. Form. | C36H44FN5O4 |
Mol. Mass. | 629.7641 |
SMILES | CCC[C@@H]1N(CCN([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H]1CCCCN1 |r| |
Structure |
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