| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50265193 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_497074 (CHEMBL997710) |
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| Ki | 1908±n/a nM |
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| Citation |  Butini, S; Guarino, E; Campiani, G; Brindisi, M; Coccone, SS; Fiorini, I; Novellino, E; Belinskaya, T; Saxena, A; Gemma, S Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity. Bioorg Med Chem Lett18:5213-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
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| Type: | Enzyme |
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| Mol. Mass.: | 67792.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22303 |
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| Residue: | 614 |
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| Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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| BDBM50265193 |
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| n/a |
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| Name | BDBM50265193 |
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| Synonyms: | (S)-2-amino-N-(2-oxo-2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl)-3-phenylpropanamide | CHEMBL495711 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N4O2 |
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| Mol. Mass. | 402.4888 |
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| SMILES | N[C@@H](Cc1ccccc1)C(=O)NCC(=O)Nc1c2CCCCc2nc2ccccc12 |r| |
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| Structure | 
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