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TargetGlycogen synthase kinase-3 beta
LigandBDBM50275499
Substrate/Competitorn/a
Meas. Tech.ChEMBL_497142 (CHEMBL1001222)
IC50 2200±n/a nM
Citation Cheung, M; Harris, PA; Badiang, JG; Peckham, GE; Chamberlain, SD; Alberti, MJ; Jung, DK; Harris, SS; Bramson, NH; Epperly, AH; Stimpson, SA; Peel, MR The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors. Bioorg Med Chem Lett18:5428-30 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50275499
n/a
NameBDBM50275499
Synonyms:2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo-[1,5-a]pyridine | CHEMBL485745
TypeSmall organic molecule
Emp. Form.C18H12FN3
Mol. Mass.289.3064
SMILESFc1ccc(cc1)-c1nn2ccccc2c1-c1ccncc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: