Compile Data Set for Download or QSAR

Found 103 hits with Last Name = 'jung' and Initial = 'dk'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14046 (Aminofurazanyl-azabenzimidazole 6m | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN(C)C)cc4)c3)cc12)-c1nonc1N Show InChI InChI=1S/C27H28N8O4/c1-4-35-22-15-23(29-16-21(22)31-26(35)24-25(28)33-39-32-24)38-20-7-5-6-18(14-20)30-27(36)17-8-10-19(11-9-17)37-13-12-34(2)3/h5-11,14-16H,4,12-13H2,1-3H3,(H2,28,33)(H,30,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14045 (Aminofurazanyl-azabenzimidazole 6l | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(CN5CCOCC5)cc4)c3)cc12)-c1nonc1N Show InChI InChI=1S/C28H28N8O4/c1-2-36-23-15-24(30-16-22(23)32-27(36)25-26(29)34-40-33-25)39-21-5-3-4-20(14-21)31-28(37)19-8-6-18(7-9-19)17-35-10-12-38-13-11-35/h3-9,14-16H,2,10-13,17H2,1H3,(H2,29,34)(H,31,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14044 (Aminofurazanyl-azabenzimidazole 6k | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(CN(C)C)cc4)c3)cc12)-c1nonc1N Show InChI InChI=1S/C26H26N8O3/c1-4-34-21-13-22(28-14-20(21)30-25(34)23-24(27)32-37-31-23)36-19-7-5-6-18(12-19)29-26(35)17-10-8-16(9-11-17)15-33(2)3/h5-14H,4,15H2,1-3H3,(H2,27,32)(H,29,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14043 (Aminofurazanyl-azabenzimidazole 6j | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(CN)cc4)c3)cc12)-c1nonc1N Show InChI InChI=1S/C24H22N8O3/c1-2-32-19-11-20(27-13-18(19)29-23(32)21-22(26)31-35-30-21)34-17-5-3-4-16(10-17)28-24(33)15-8-6-14(12-25)7-9-15/h3-11,13H,2,12,25H2,1H3,(H2,26,31)(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14042 (Aminofurazanyl-azabenzimidazole 6i | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(cc4)N4CCOCC4)c3)cc12)-c1nonc1N Show InChI InChI=1S/C27H26N8O4/c1-2-35-22-15-23(29-16-21(22)31-26(35)24-25(28)33-39-32-24)38-20-5-3-4-18(14-20)30-27(36)17-6-8-19(9-7-17)34-10-12-37-13-11-34/h3-9,14-16H,2,10-13H2,1H3,(H2,28,33)(H,30,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14035 (Aminofurazanyl-azabenzimidazole 6c | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(C)=O)c3)cc12)-c1nonc1N Show InChI InChI=1S/C18H17N7O3/c1-3-25-14-8-15(27-12-6-4-5-11(7-12)21-10(2)26)20-9-13(14)22-18(25)16-17(19)24-28-23-16/h4-9H,3H2,1-2H3,(H2,19,24)(H,21,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168577 (4-(1-Cyclopropyl-1H-imidazo[4,5-c]pyridin-2-yl)-fu...) Show SMILES Nc1nonc1-c1nc2cnccc2n1C1CC1 Show InChI InChI=1S/C11H10N6O/c12-10-9(15-18-16-10)11-14-7-5-13-4-3-8(7)17(11)6-1-2-6/h3-6H,1-2H2,(H2,12,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14047 (Aminofurazanyl-azabenzimidazole 6n | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc12)-c1nonc1N Show InChI InChI=1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14041 (Aminofurazanyl-azabenzimidazole 6h | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(cc4)N(C)C)c3)cc12)-c1nonc1N Show InChI InChI=1S/C25H24N8O3/c1-4-33-20-13-21(27-14-19(20)29-24(33)22-23(26)31-36-30-22)35-18-7-5-6-16(12-18)28-25(34)15-8-10-17(11-9-15)32(2)3/h5-14H,4H2,1-3H3,(H2,26,31)(H,28,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168587 (4-(1-Cyclohexyl-1H-imidazo[4,5-c]pyridin-2-yl)-fur...) Show SMILES Nc1nonc1-c1nc2cnccc2n1C1CCCCC1 Show InChI InChI=1S/C14H16N6O/c15-13-12(18-21-19-13)14-17-10-8-16-7-6-11(10)20(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H2,15,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM14032 (4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...) Show SMILES CCn1c(nc2cnccc12)-c1nonc1N Show InChI InChI=1S/C10H10N6O/c1-2-16-7-3-4-12-5-6(7)13-10(16)8-9(11)15-17-14-8/h3-5H,2H2,1H3,(H2,11,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14040 (Aminofurazanyl-azabenzimidazole 6g | N-(3-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccccc4)c3)cc12)-c1nonc1N Show InChI InChI=1S/C23H19N7O3/c1-2-30-18-12-19(25-13-17(18)27-22(30)20-21(24)29-33-28-20)32-16-10-6-9-15(11-16)26-23(31)14-7-4-3-5-8-14/h3-13H,2H2,1H3,(H2,24,29)(H,26,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14033 (4-{1-ethyl-6-methoxy-1H-imidazo[4,5-c]pyridin-2-yl...) Show SMILES CCn1c(nc2cnc(OC)cc12)-c1nonc1N Show InChI InChI=1S/C11H12N6O2/c1-3-17-7-4-8(18-2)13-5-6(7)14-11(17)9-10(12)16-19-15-9/h4-5H,3H2,1-2H3,(H2,12,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14050 (N-(1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoro...) Show SMILES CC1=C(C(CC(=O)N1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI InChI=1S/C21H17F3N4O2/c1-11-19(20(30)27-15-6-7-17-13(8-15)10-25-28-17)16(9-18(29)26-11)12-2-4-14(5-3-12)21(22,23)24/h2-8,10,16H,9H2,1H3,(H,25,28)(H,26,29)(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 6-9 (2007) Article DOI: 10.1021/jm0609014 BindingDB Entry DOI: 10.7270/Q298858V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14056 (N-(7-chloro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...) Show SMILES CC1=C(C(CC(=O)N1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1cc(Cl)c2[nH]ncc2c1 |t:1| Show InChI InChI=1S/C21H16ClF3N4O2/c1-10-18(20(31)28-14-6-12-9-26-29-19(12)16(22)7-14)15(8-17(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-7,9,15H,8H2,1H3,(H,26,29)(H,27,30)(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 6-9 (2007) Article DOI: 10.1021/jm0609014 BindingDB Entry DOI: 10.7270/Q298858V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14051 (4-(3,4-Dichlorophenyl)-N-1H-indazol-5-yl-2-methyl-...) Show SMILES CC1=C(C(CC(=O)N1)c1ccc(Cl)c(Cl)c1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI InChI=1S/C20H16Cl2N4O2/c1-10-19(20(28)25-13-3-5-17-12(6-13)9-23-26-17)14(8-18(27)24-10)11-2-4-15(21)16(22)7-11/h2-7,9,14H,8H2,1H3,(H,23,26)(H,24,27)(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 6-9 (2007) Article DOI: 10.1021/jm0609014 BindingDB Entry DOI: 10.7270/Q298858V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14053 (2-methyl-N-(3-methyl-1H-indazol-5-yl)-6-oxo-4-[4-(...) Show SMILES Cc1n[nH]c2ccc(NC(=O)C3=C(C)NC(=O)CC3c3ccc(cc3)C(F)(F)F)cc12 |c:11| Show InChI InChI=1S/C22H19F3N4O2/c1-11-16-9-15(7-8-18(16)29-28-11)27-21(31)20-12(2)26-19(30)10-17(20)13-3-5-14(6-4-13)22(23,24)25/h3-9,17H,10H2,1-2H3,(H,26,30)(H,27,31)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 6-9 (2007) Article DOI: 10.1021/jm0609014 BindingDB Entry DOI: 10.7270/Q298858V
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50358043 (CHEMBL1794051 | GW-5074) Show SMILES OC1Nc2ccc(I)cc2C1=Cc1cc(Br)c(O)c(Br)c1 Show InChI InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14052 (N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6...) Show SMILES CC1=C(C(CC(=O)N1)c1ccc2ccccc2c1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI InChI=1S/C24H20N4O2/c1-14-23(24(30)27-19-8-9-21-18(11-19)13-25-28-21)20(12-22(29)26-14)17-7-6-15-4-2-3-5-16(15)10-17/h2-11,13,20H,12H2,1H3,(H,25,28)(H,26,29)(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 6-9 (2007) Article DOI: 10.1021/jm0609014 BindingDB Entry DOI: 10.7270/Q298858V
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50366677 (CHEMBL1794050) Show SMILES Oc1c(Br)cc(C=C2C(=O)Nc3ccc(cc23)-c2cccnc2)cc1Br Show InChI InChI=1S/C20H12Br2N2O2/c21-16-7-11(8-17(22)19(16)25)6-15-14-9-12(13-2-1-5-23-10-13)3-4-18(14)24-20(15)26/h1-10,25H,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168581 (4-(1-Phenyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan...) Show SMILES Nc1nonc1-c1nc2cnccc2n1-c1ccccc1 Show InChI InChI=1S/C14H10N6O/c15-13-12(18-21-19-13)14-17-10-8-16-7-6-11(10)20(14)9-4-2-1-3-5-9/h1-8H,(H2,15,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168578 (4-[1-(1-Amino-butyl)-1H-imidazo[4,5-c]pyridin-2-yl...) Show SMILES CCCC(N)n1c(nc2cnccc12)-c1nonc1N Show InChI InChI=1S/C12H15N7O/c1-2-3-9(13)19-8-4-5-15-6-7(8)16-12(19)10-11(14)18-20-17-10/h4-6,9H,2-3,13H2,1H3,(H2,14,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085414 (3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylide...) Show SMILES COC(=O)c1ccc2NC(=O)\C(=C/c3cc(Br)c(O)c(Br)c3)c2c1 Show InChI InChI=1S/C17H11Br2NO4/c1-24-17(23)9-2-3-14-10(7-9)11(16(22)20-14)4-8-5-12(18)15(21)13(19)6-8/h2-7,21H,1H3,(H,20,22)/b11-4-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14037 (1-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H...) Show SMILES CCn1c(nc2cnc(Oc3cccc(c3)C(C)=O)cc12)-c1nonc1N Show InChI InChI=1S/C18H16N6O3/c1-3-24-14-8-15(26-12-6-4-5-11(7-12)10(2)25)20-9-13(14)21-18(24)16-17(19)23-27-22-16/h4-9H,3H2,1-2H3,(H2,19,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14055 (N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...) Show SMILES CC1=C(C(CC(=O)N1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1cc2cn[nH]c2cc1F |t:1| Show InChI InChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 6-9 (2007) Article DOI: 10.1021/jm0609014 BindingDB Entry DOI: 10.7270/Q298858V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14048 (4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-...) Show SMILES CC1=NC(=O)NC(C1C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(F)cc1 |t:1| Show InChI InChI=1S/C19H16FN5O2/c1-10-16(17(24-19(27)22-10)11-2-4-13(20)5-3-11)18(26)23-14-6-7-15-12(8-14)9-21-25-15/h2-9,16-17H,1H3,(H,21,25)(H,23,26)(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 6-9 (2007) Article DOI: 10.1021/jm0609014 BindingDB Entry DOI: 10.7270/Q298858V
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085408 (2-Amino-8-[1-(3,5-dibromo-4-hydroxy-phenyl)-meth-(...) Show SMILES Nc1nc2c3\C(=C\c4cc(Br)c(O)c(Br)c4)C(=O)Nc3ccc2s1 Show InChI InChI=1S/C16H9Br2N3O2S/c17-8-4-6(5-9(18)14(8)22)3-7-12-10(20-15(7)23)1-2-11-13(12)21-16(19)24-11/h1-5,22H,(H2,19,21)(H,20,23)/b7-3-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168601 (4-(1-Piperidin-4-yl-1H-imidazo[4,5-c]pyridin-2-yl)...) Show SMILES Nc1nonc1-c1nc2cnccc2n1C1CCNCC1 Show InChI InChI=1S/C13H15N7O/c14-12-11(18-21-19-12)13-17-9-7-16-6-3-10(9)20(13)8-1-4-15-5-2-8/h3,6-8,15H,1-2,4-5H2,(H2,14,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168594 (2-(4-Amino-furazan-3-yl)-1-ethyl-1H-benzoimidazol-...) Show SMILES CCn1c(nc2cc(O)ccc12)-c1nonc1N Show InChI InChI=1S/C11H11N5O2/c1-2-16-8-4-3-6(17)5-7(8)13-11(16)9-10(12)15-18-14-9/h3-5,17H,2H2,1H3,(H2,12,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14039 (4-[6-(3-aminophenoxy)-1-ethyl-1H-imidazo[4,5-c]pyr...) Show SMILES CCn1c(nc2cnc(Oc3cccc(N)c3)cc12)-c1nonc1N Show InChI InChI=1S/C16H15N7O2/c1-2-23-12-7-13(24-10-5-3-4-9(17)6-10)19-8-11(12)20-16(23)14-15(18)22-25-21-14/h3-8H,2,17H2,1H3,(H2,18,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085412 (5-Benzoyl-3-[1-(3,5-dibromo-4-hydroxy-phenyl)-meth...) Show SMILES Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2ccccc2)cc1Br Show InChI InChI=1S/C22H13Br2NO3/c23-17-9-12(10-18(24)21(17)27)8-16-15-11-14(6-7-19(15)25-22(16)28)20(26)13-4-2-1-3-5-13/h1-11,27H,(H,25,28)/b16-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14032 (4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...) Show SMILES CCn1c(nc2cnccc12)-c1nonc1N Show InChI InChI=1S/C10H10N6O/c1-2-16-7-3-4-12-5-6(7)13-10(16)8-9(11)15-17-14-8/h3-5H,2H2,1H3,(H2,11,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168576 (3-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-pyrazin-...) Show SMILES CCn1c(nc2cnccc12)-c1nccnc1N Show InChI InChI=1S/C12H12N6/c1-2-18-9-3-4-14-7-8(9)17-12(18)10-11(13)16-6-5-15-10/h3-7H,2H2,1H3,(H2,13,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085418 (3-(3,5-dibromo-4-hydroxybenzylidene)-5-(cyclopropa...) Show SMILES Oc1c(Br)cc(C=C2C(=O)Nc3ccc(cc23)C(=O)C2CC2)cc1Br |w:6.5| Show InChI InChI=1S/C19H13Br2NO3/c20-14-6-9(7-15(21)18(14)24)5-13-12-8-11(17(23)10-1-2-10)3-4-16(12)22-19(13)25/h3-8,10,24H,1-2H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085417 (3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylide...) Show SMILES OCCN(CCO)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc(Br)c(O)c(Br)c3)c2c1 Show InChI InChI=1S/C19H18Br2N2O6S/c20-15-8-11(9-16(21)18(15)26)7-14-13-10-12(1-2-17(13)22-19(14)27)30(28,29)23(3-5-24)4-6-25/h1-2,7-10,24-26H,3-6H2,(H,22,27)/b14-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14034 (4-{1-ethyl-6-phenoxy-1H-imidazo[4,5-c]pyridin-2-yl...) Show SMILES CCn1c(nc2cnc(Oc3ccccc3)cc12)-c1nonc1N Show InChI InChI=1S/C16H14N6O2/c1-2-22-12-8-13(23-10-6-4-3-5-7-10)18-9-11(12)19-16(22)14-15(17)21-24-20-14/h3-9H,2H2,1H3,(H2,17,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085413 (3-(3,5-dichloro-4-hydroxybenzylidene)-5-phenylindo...) Show SMILES Oc1c(Cl)cc(\C=C2/C(=O)Nc3ccc(cc23)-c2ccccc2)cc1Cl Show InChI InChI=1S/C21H13Cl2NO2/c22-17-9-12(10-18(23)20(17)25)8-16-15-11-14(13-4-2-1-3-5-13)6-7-19(15)24-21(16)26/h1-11,25H,(H,24,26)/b16-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50169697 (CHEMBL182254 | [3-Chloro-4-(3-fluoro-benzyloxy)-ph...) Show SMILES Fc1cccc(COc2ccc(Nc3ncnc4nn5ccccc5c34)cc2Cl)c1 Show InChI InChI=1S/C22H15ClFN5O/c23-17-11-16(7-8-19(17)30-12-14-4-3-5-15(24)10-14)27-21-20-18-6-1-2-9-29(18)28-22(20)26-13-25-21/h1-11,13H,12H2,(H,25,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	7.5	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibitory concentration against EGFR by using [gamma-33P]-ATP as radioligand in pH 7.5				Bioorg Med Chem Lett 15: 3778-81 (2005) Article DOI: 10.1016/j.bmcl.2005.05.100 BindingDB Entry DOI: 10.7270/Q2P84BDM
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14038 (4-[1-ethyl-6-(3-methanesulfonylphenoxy)-1H-imidazo...) Show SMILES CCn1c(nc2cnc(Oc3cccc(c3)S(C)(=O)=O)cc12)-c1nonc1N Show InChI InChI=1S/C17H16N6O4S/c1-3-23-13-8-14(26-10-5-4-6-11(7-10)28(2,24)25)19-9-12(13)20-17(23)15-16(18)22-27-21-15/h4-9H,3H2,1-2H3,(H2,18,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168595 (4-(1-Ethyl-5-fluoro-1H-benzoimidazol-2-yl)-furazan...) Show SMILES CCn1c(nc2cc(F)ccc12)-c1nonc1N Show InChI InChI=1S/C11H10FN5O/c1-2-17-8-4-3-6(12)5-7(8)14-11(17)9-10(13)16-18-15-9/h3-5H,2H2,1H3,(H2,13,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085411 (3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...) Show SMILES Oc1c(Cl)cc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2ccco2)cc1Cl Show InChI InChI=1S/C20H11Cl2NO4/c21-14-7-10(8-15(22)19(14)25)6-13-12-9-11(3-4-16(12)23-20(13)26)18(24)17-2-1-5-27-17/h1-9,25H,(H,23,26)/b13-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085411 (3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...) Show SMILES Oc1c(Cl)cc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2ccco2)cc1Cl Show InChI InChI=1S/C20H11Cl2NO4/c21-14-7-10(8-15(22)19(14)25)6-13-12-9-11(3-4-16(12)23-20(13)26)18(24)17-2-1-5-27-17/h1-9,25H,(H,23,26)/b13-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50275583 (7-ethoxy-2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazo...) Show SMILES CCOc1cccc2c(c(nn12)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H16FN3O/c1-2-25-18-5-3-4-17-19(14-10-12-22-13-11-14)20(23-24(17)18)15-6-8-16(21)9-7-15/h3-13H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GST-fused p38alpha (unknown origin) expressed in Escherichia coli				Bioorg Med Chem Lett 18: 5428-30 (2008) Article DOI: 10.1016/j.bmcl.2008.09.040 BindingDB Entry DOI: 10.7270/Q27S7NM9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50169696 ((4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-f...) Show SMILES Clc1cc(Nc2ncnc3nn4ccccc4c23)ccc1OCc1ccccc1 Show InChI InChI=1S/C22H16ClN5O/c23-17-12-16(9-10-19(17)29-13-15-6-2-1-3-7-15)26-21-20-18-8-4-5-11-28(18)27-22(20)25-14-24-21/h1-12,14H,13H2,(H,24,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibitory concentration against EGFR by using [gamma-33P]-ATP as radioligand in pH 7.5				Bioorg Med Chem Lett 15: 3778-81 (2005) Article DOI: 10.1016/j.bmcl.2005.05.100 BindingDB Entry DOI: 10.7270/Q2P84BDM
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14049 (4-(4-Fluorophenyl)-N-1H-indazol-5-yl-2-methyl-6-ox...) Show SMILES CC1=C(C(CC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI InChI=1S/C20H17FN4O2/c1-11-19(16(9-18(26)23-11)12-2-4-14(21)5-3-12)20(27)24-15-6-7-17-13(8-15)10-22-25-17/h2-8,10,16H,9H2,1H3,(H,22,25)(H,23,26)(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 6-9 (2007) Article DOI: 10.1021/jm0609014 BindingDB Entry DOI: 10.7270/Q298858V
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Homo sapiens (Human))	BDBM50168586 (4-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-5-methyl...) Show SMILES CCn1c(nc2cnccc12)-c1c(C)[nH]nc1N |(11.15,-8.55,;12.2,-7.41,;11.71,-5.96,;12.62,-4.7,;11.71,-3.45,;10.24,-3.93,;8.92,-3.16,;7.59,-3.93,;7.59,-5.48,;8.92,-6.24,;10.24,-5.48,;14.15,-4.58,;15.15,-5.75,;14.78,-7.24,;16.57,-5.17,;16.46,-3.64,;14.97,-3.26,;14.39,-1.85,)| Show InChI InChI=1S/C12H14N6/c1-3-18-9-4-5-14-6-8(9)15-12(18)10-7(2)16-17-11(10)13/h4-6H,3H2,1-2H3,(H3,13,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration exhibited towards MSK-1				Bioorg Med Chem Lett 15: 3402-6 (2005) Article DOI: 10.1016/j.bmcl.2005.05.021 BindingDB Entry DOI: 10.7270/Q2Z037P9
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50169697 (CHEMBL182254 | [3-Chloro-4-(3-fluoro-benzyloxy)-ph...) Show SMILES Fc1cccc(COc2ccc(Nc3ncnc4nn5ccccc5c34)cc2Cl)c1 Show InChI InChI=1S/C22H15ClFN5O/c23-17-11-16(7-8-19(17)30-12-14-4-3-5-15(24)10-14)27-21-20-18-6-1-2-9-29(18)28-22(20)26-13-25-21/h1-11,13H,12H2,(H,25,26,27,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>63	n/a	n/a	n/a	n/a	7.5	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibitory concentration against ErbB-2 protein tyrosine kinase by using [gamma-33P]-ATP as radioligand in pH 7.5				Bioorg Med Chem Lett 15: 3778-81 (2005) Article DOI: 10.1016/j.bmcl.2005.05.100 BindingDB Entry DOI: 10.7270/Q2P84BDM
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50085416 (5-(2-Chloro-acetyl)-3-[1-(3,5-dibromo-4-hydroxy-ph...) Show SMILES Oc1c(Br)cc(C=C2C(=O)Nc3ccc(cc23)C(=O)CCl)cc1Br |w:6.5| Show InChI InChI=1S/C17H10Br2ClNO3/c18-12-4-8(5-13(19)16(12)23)3-11-10-6-9(15(22)7-20)1-2-14(10)21-17(11)24/h1-6,23H,7H2,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description Inhibition of cRaf1 kinase in cascade assay				Bioorg Med Chem Lett 10: 223-6 (2000) BindingDB Entry DOI: 10.7270/Q2Q240R6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50275614 (2-(4-fluorophenyl)-3-(pyridin-4-yl)-7-(2,2,2-trifl...) Show SMILES Fc1ccc(cc1)-c1nn2c(OCC(F)(F)F)cccc2c1-c1ccncc1 Show InChI InChI=1S/C20H13F4N3O/c21-15-6-4-14(5-7-15)19-18(13-8-10-25-11-9-13)16-2-1-3-17(27(16)26-19)28-12-20(22,23)24/h1-11H,12H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GST-fused p38alpha (unknown origin) expressed in Escherichia coli				Bioorg Med Chem Lett 18: 5428-30 (2008) Article DOI: 10.1016/j.bmcl.2008.09.040 BindingDB Entry DOI: 10.7270/Q27S7NM9
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14036 (Aminofurazanyl-azabenzimidazole 6d | N-(4-{[2-(4-a...) Show SMILES CCn1c(nc2cnc(Oc3ccc(NC(C)=O)cc3)cc12)-c1nonc1N Show InChI InChI=1S/C18H17N7O3/c1-3-25-14-8-15(27-12-6-4-11(5-7-12)21-10(2)26)20-9-13(14)22-18(25)16-17(19)24-28-23-16/h4-9H,3H2,1-2H3,(H2,19,24)(H,21,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...				J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB
					More data for this Ligand-Target Pair

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