| Reaction Details |
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 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
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| Ligand | BDBM50275499 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_497152 (CHEMBL1001232) |
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| IC50 | >10000±n/a nM |
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| Citation |  Cheung, M; Harris, PA; Badiang, JG; Peckham, GE; Chamberlain, SD; Alberti, MJ; Jung, DK; Harris, SS; Bramson, NH; Epperly, AH; Stimpson, SA; Peel, MR The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors. Bioorg Med Chem Lett18:5428-30 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
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| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
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| Synonyms: | PDHK4 | PDK4 | PDK4_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 4 (PDK4) | Pyruvate dehydrogenase kinase isoform 4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 46469.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16654 |
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| Residue: | 411 |
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| Sequence: | MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQE
LPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL
IKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF
SDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIH
IVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPL
RIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDA
IIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
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| BDBM50275499 |
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| n/a |
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| Name | BDBM50275499 |
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| Synonyms: | 2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo-[1,5-a]pyridine | CHEMBL485745 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12FN3 |
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| Mol. Mass. | 289.3064 |
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| SMILES | Fc1ccc(cc1)-c1nn2ccccc2c1-c1ccncc1 |
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| Structure | 
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