| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50246509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559677 (CHEMBL1010075) |
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| IC50 | >150000±n/a nM |
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| Citation |  Zanatta, N; Amaral, SS; Dos Santos, JM; de Mello, DL; Fernandes, Lda S; Bonacorso, HG; Martins, MA; Andricopulo, AD; Borchhardt, DM Convergent synthesis and cruzain inhibitory activity of novel 2-(N'-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines. Bioorg Med Chem16:10236-43 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50246509 |
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| n/a |
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| Name | BDBM50246509 |
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| Synonyms: | 2-(N'-2-Methoxy-benzylidenehydrazino)-6-methyl-4-trifluoromethyl-pyri-midine | CHEMBL453634 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13F3N4O |
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| Mol. Mass. | 310.2744 |
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| SMILES | COc1ccccc1CN=Nc1nc(C)cc(n1)C(F)(F)F |w:10.11| |
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| Structure | 
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