Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBradykinin B1 receptor
LigandBDBM50254458
Substrate/Competitorn/a
Meas. Tech.ChEMBL_560709
Ki 267±n/a nM
Citation Cole AGMetzger ABrescia MRQin LYAppell KCBrain CTHallett AGanju PDenholm AAWareing JRRitchie TJDrake GMBevan SJMacGloinn AMcBryde APatel VOakley PJNunez XGstach HSchneider PBaldwin JJDolle REMcDonald EHenderson I Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists. Bioorg Med Chem Lett 19:119-22 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bradykinin B1 receptor
Name:Bradykinin B1 receptor
Synonyms:B1 BRADYKININ | B1 bradykinin receptor | B1R | BK-1 receptor
Type:Enzyme
Mol. Mass.:40508.87
Organism:Homo sapiens (Human)
Description:P46663
Residue:353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50254458
n/a
NameBDBM50254458
Synonyms:CHEMBL452238 | N-(2-chlorobenzyl)-2-(N-(4-isobutoxy-3-methoxybenzyl)-4-(piperidin-1-ylmethyl)phenylsulfonamido)acetamide
TypeSmall organic molecule
Emp. Form.C33H42ClN3O5S
Mol. Mass.628.222
SMILESCOc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: