| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl2-associated agonist of cell death |
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| Ligand | BDBM50254583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_558764 (CHEMBL1019893) |
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| IC50 | 2410±n/a nM |
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| Citation |  Porter, J; Payne, A; de Candole, B; Ford, D; Hutchinson, B; Trevitt, G; Turner, J; Edwards, C; Watkins, C; Whitcombe, I; Davis, J; Stubberfield, C Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors. Bioorg Med Chem Lett19:230-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl2-associated agonist of cell death |
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| Name: | Bcl2-associated agonist of cell death |
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| Synonyms: | BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18393.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_478760 |
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| Residue: | 168 |
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| Sequence: | MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH
HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE
FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
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| BDBM50254583 |
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| n/a |
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| Name | BDBM50254583 |
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| Synonyms: | 4-bromo-1-(2-((S)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-5-methyl-N,N-diphenyl-1H-pyrazole-3-carboxamide | CHEMBL509788 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H29BrN4O3 |
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| Mol. Mass. | 621.523 |
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| SMILES | Cc1c(Br)c(nn1-c1ccccc1C(=O)N1Cc2ccccc2C[C@H]1CO)C(=O)N(c1ccccc1)c1ccccc1 |r| |
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| Structure | 
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