| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP1 subtype |
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| Ligand | BDBM50259548 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_544238 (CHEMBL1010713) |
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| IC50 | 12.6±n/a nM |
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| Citation |  Hall, A; Brown, SH; Budd, C; Clayton, NM; Giblin, GM; Goldsmith, P; Hayhow, TG; Hurst, DN; Naylor, A; Anthony Rawlings, D; Scoccitti, T; Wilson, AW; Winchester, WJ Discovery of GSK345931A: An EP(1) receptor antagonist with efficacy in preclinical models of inflammatory pain. Bioorg Med Chem Lett19:497-501 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP1 subtype |
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| Name: | Prostaglandin E2 receptor EP1 subtype |
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| Synonyms: | PE2R1_RAT | Prostanoid EP1 receptor | Ptger1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43080.10 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P70597 |
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| Residue: | 405 |
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| Sequence: | MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLA
QVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMV
FFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGH
YELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRR
SRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVG
QLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQA
MLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
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| BDBM50259548 |
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| n/a |
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| Name | BDBM50259548 |
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| Synonyms: | 6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-2-carboxylate Sodium | CHEMBL467510 | sodium 6-(5'-chloro-2'-isobutoxybiphenyl-2-yl)picolinate |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19ClNO3 |
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| Mol. Mass. | 380.845 |
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| SMILES | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(n1)C([O-])=O |
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| Structure | 
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