Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50266173 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_544515 (CHEMBL1013487) |
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IC50 | 24.0±n/a nM |
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Citation | Enomoto, H; Morikawa, Y; Miyake, Y; Tsuji, F; Mizuchi, M; Suhara, H; Fujimura, K; Horiuchi, M; Ban, M Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett19:442-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_CAVPO | LTA4H |
Type: | PROTEIN |
Mol. Mass.: | 68972.78 |
Organism: | Cavia porcellus |
Description: | ChEMBL_544515 |
Residue: | 611 |
Sequence: | MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDL
TIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAP
DPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETES
MLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
TWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGET
QAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSI
TTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVT
AMLVGKDLKVE
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BDBM50266173 |
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n/a |
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Name | BDBM50266173 |
Synonyms: | (R)-3-(4-tert-butylbenzylthio)-2-((S)-3-mercapto-2-methylpropanamido)propanoic acid | CHEMBL463320 |
Type | Small organic molecule |
Emp. Form. | C18H27NO3S2 |
Mol. Mass. | 369.542 |
SMILES | C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)C(C)(C)C)C(O)=O |r| |
Structure |
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