| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
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| Ligand | BDBM50266138 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_544515 (CHEMBL1013487) |
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| IC50 | 140±n/a nM |
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| Citation |  Enomoto, H; Morikawa, Y; Miyake, Y; Tsuji, F; Mizuchi, M; Suhara, H; Fujimura, K; Horiuchi, M; Ban, M Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett19:442-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukotriene A-4 hydrolase |
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| Name: | Leukotriene A-4 hydrolase |
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| Synonyms: | LKHA4_CAVPO | LTA4H |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68972.78 |
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| Organism: | Cavia porcellus |
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| Description: | ChEMBL_544515 |
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| Residue: | 611 |
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| Sequence: | MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDL
TIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAP
DPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETES
MLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
TWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGET
QAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSI
TTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVT
AMLVGKDLKVE
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| BDBM50266138 |
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| n/a |
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| Name | BDBM50266138 |
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| Synonyms: | (R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-(trifluoromethyl)benzylthio)propanoic acid | CHEMBL459961 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18F3NO3S2 |
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| Mol. Mass. | 381.434 |
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| SMILES | C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)C(F)(F)F)C(O)=O |r| |
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| Structure | 
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