Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50273932 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_561948 (CHEMBL1021466) |
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Ki | >10000±n/a nM |
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Citation | Kurimura, M; Liu, H; Sulima, A; Hashimoto, A; Przybyl, AK; Ohshima, E; Kodato, S; Deschamps, JR; Dersch, CM; Rothman, RB; Lee, YS; Jacobson, AE; Rice, KC Probes for narcotic receptor mediated phenomena. 37. Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers. J Med Chem51:7866-81 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50273932 |
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n/a |
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Name | BDBM50273932 |
Synonyms: | (4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-methyl-1H-4,11bmethanobenzofuro[3,2-d]azocine-10-ol | CHEMBL517866 |
Type | Small organic molecule |
Emp. Form. | C15H19NO2 |
Mol. Mass. | 245.3169 |
SMILES | CN1CC[C@@]23C[C@@H]1CC[C@H]2Oc1ccc(O)cc31 |r| |
Structure |
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