| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
|---|
| Ligand | BDBM50246609 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_561010 (CHEMBL1015250) |
|---|
| EC50 | 15±n/a nM |
|---|
| Citation |  Yea, CM; Allan, CE; Ashworth, DM; Barnett, J; Baxter, AJ; Broadbridge, JD; Franklin, RJ; Hampton, SL; Hudson, P; Horton, JA; Jenkins, PD; Penson, AM; Pitt, GR; Rivière, P; Robson, PA; Rooker, DP; Semple, G; Sheppard, A; Haigh, RM; Roe, MB New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem51:8124-34 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vasopressin V2 receptor |
|---|
| Name: | Vasopressin V2 receptor |
|---|
| Synonyms: | AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor |
|---|
| Type: | G-protein coupled receptor |
|---|
| Mol. Mass.: | 40761.85 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 371 |
|---|
| Sequence: | MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLG
ALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQ
RDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGP
SERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEA
PLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCAT
ASSSLMKDTPS
|
|
|
|---|
| BDBM50246609 |
|---|
| n/a |
|---|
| Name | BDBM50246609 |
|---|
| Synonyms: | (4R)-4-Ethoxy-1-(2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl)benzyl-carbamoyl)-L-proline-N,N-dimethylamide | CHEMBL472697 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H38N4O4 |
|---|
| Mol. Mass. | 506.6364 |
|---|
| SMILES | CCO[C@@H]1C[C@H](N(C1)C(=O)NCc1ccc(cc1C)C(=O)N1CCCCc2ccccc12)C(=O)N(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
